Boston, MA -- A reanalysis of nicotine yield from major brand name cigarettes sold in Massachusetts from 1997 to 2005 has confirmed that manufacturers have steadily increased the levels of this agent in cigarettes. This independent analysis, based on data submitted to the Massachusetts Department of Public Health (MDPH) by the manufacturers, found that increases in smoke nicotine yield per cigarette averaged 1.6 percent each year, or about 11 percent over a seven-year period (1998-2005). Nicotine is the primary addictive agent in cigarettes.

In addition to confirming the magnitude of the increase, first reported in August, 2006 by MDPH, researchers from the Harvard School of Public Health (HSPH) extended the analysis to:

   1. ascertain how manufacturers accomplished the increase -- not only by intensifying the concentration of nicotine in the tobacco but also by modifying several design features of cigarettes to increase the number of puffs per cigarette. The end result is a product that is potentially more addictive.

   2. examine all market categories -- finding that smoke nicotine yields were increased in the cigarettes of each of the four major manufacturers and across all the major cigarette market categories (e.g. mentholated, non-mentholated, full-flavor, light, ultralight).

Findings from the report "Trends in Smoke Nicotine Yield and Relationship to Design Characteristics Among Popular U.S. Cigarette Brands" will be presented at Harvard School of Public Health, Bldg 3/Rm 203, on Thurs., Jan. 18, 2007, 12 p.m.. The presentation is open to the media.

The analysis was performed by a research team from the Tobacco Control Research Program at HSPH led by program director Gregory Connolly, professor of the practice of public health, and Howard Koh, associate dean for public health practice at HSPH and a former commissioner of public health for the Commonwealth of Massachusetts (1997-2003). The other co-investigators were HSPH researchers Hillel R. Alpert and Geoffrey Ferris Wayne.

"Cigarettes are finely-tuned drug delivery devices, designed to perpetuate a tobacco pandemic," said former Commissioner Koh. "Yet precise information about these products remains shrouded in secrecy, hidden from the public. Policy actions today requiring the tobacco industry to disclose critical information about nicotine and product design could protect the next generation from the tragedy of addiction."

Said Connolly: "Our findings call into serious question whether the tobacco industry has changed at all in its pursuit of addicting smokers since signing the Master Settlement Agreement of 1998 with the State Attorneys General. Our analysis shows that the companies have been subtly increasing the drug nicotine year by year in their cigarettes, without any warning to consumers, since the settlement. Scrutiny by the Attorneys General is imperative. Proposed federal legislation has been filed by Senator Edward Kennedy (D-Ma.) that would address this abuse and bring the tobacco industry under the rules that regulate other manufacturers of drugs."

Beginning in 1997, Massachusetts regulations have required an annual report to be filed with the MDPH by all manufacturers of cigarettes sold in Massachusetts. The reported data include machine-based measures of nicotine yield as well as measures of cigarette design related to nicotine delivery.

The Tobacco Research Program at HSPH obtained from the MDPH a complete set of brand-specific data from 1997 to 2005 and analyzed trends in smoke nicotine yield.

The discovery of an 11 percent increase in nicotine content, said Connolly, confirms recent statements by the US District Court for the District of Columbia that manufacturers have the ability to manipulate addictive additives, and, he said, "it underscores the need for continued surveillance of nicotine delivery in products created by an unregulated industry."

In an opinion in US vs. Philip Morris USA et. al. Judge Gladys Kessler wrote that tobacco companies "can and do control the level of nicotine delivered in order to create and sustain addiction" and further, that the "goal to ensure that their products deliver sufficient nicotine to create and sustain addiction influences their selection and combination of design parameters."

Cigarette smoking causes an estimated 438,000 premature deaths (or about 1 of every 5 deaths) annually in the U.S., and approximately 900,000 persons become addicted to smoking each year.

In conclusion, according to the HSPH researchers, the extended analysis of MDPH data has demonstrated its potential to reveal undisclosed hazards to human health. They suggest that MDPH amend its unique reporting requirements to include more information about cigarette and smokeless tobacco product design features that affect nicotine delivery - as well as testing of a sample of brands for the actual delivery of nicotine to the body.

WASHINGTON, D.C. and LONDON, ENGLAND - January 17, 2006 -- The Bulletin of the Atomic Scientists (BAS) is moving the minute hand of the Doomsday Clock today from seven to five minutes to midnight. Reflecting global failures to solve the problems posed by nuclear weapons and the climate crisis, the decision by the BAS Board of Directors was made in consultation with the Bulletin's Board of Sponsors, which includes 18 Nobel Laureates.

BAS announced the Clock change today at an unprecedented joint news conference held at the American Association for the Advancement of Science in Washington, DC, and the Royal Society in London. In a statement supporting the decision to move the hand of the Doomsday Clock, the BAS Board focused on two major sources of catastrophe: the perils of 27,000 nuclear weapons, 2000 of them ready to launch within minutes; and the destruction of human habitats from climate change. In articles by 14 leading scientists and security experts writing in the January-February issue of the Bulletin of the Atomic Scientists (http://www.thebulletin.org), the potential for catastrophic damage from human-made technologies is explored further.

Created in 1947 by the Bulletin of the Atomic Scientists, the Doomsday Clock has been adjusted only 17 times prior to today, most recently in February 2002 after the events of 9/11.

By moving the hand of the Clock closer to midnight--the figurative end of civilization--the BAS Board of Directors is drawing attention to the increasing dangers from the spread of nuclear weapons in a world of violent conflict, and to the catastrophic harm from climate change that is unfolding.

The BAS statement explains: "We stand at the brink of a Second Nuclear Age. Not since the first atomic bombs were dropped on Hiroshima and Nagasaki has the world faced such perilous choices. North Korea's recent test of a nuclear weapon, Iran's nuclear ambitions, a renewed emphasis on the military utility of nuclear weapons, the failure to adequately secure nuclear materials, and the continued presence of some 26,000 nuclear weapons in the United States and Russia are symptomatic of a failure to solve the problems posed by the most destructive technology on Earth."

The BAS statement continues: "The dangers posed by climate change are nearly as dire as those posed by nuclear weapons. The effects may be less dramatic in the short term than the destruction that could be wrought by nuclear explosions, but over the next three to four decades climate change could cause irremediable harm to the habitats upon which human societies depend for survival."

Stephen Hawking, a BAS sponsor, professor of mathematics at the University of Cambridge, and a fellow of The Royal Society, said: "As scientists, we understand the dangers of nuclear weapons and their devastating effects, and we are learning how human activities and technologies are affecting climate systems in ways that may forever change life on Earth. As citizens of the world, we have a duty to alert the public to the unnecessary risks that we live with every day, and to the perils we foresee if governments and societies do not take action now to render nuclear weapons obsolete and to prevent further climate change."

Kennette Benedict, executive director, Bulletin of the Atomic Scientists, said: "As we stand at the brink of a Second Nuclear Age and at the onset of unprecedented climate change, our way of thinking about the uses and control of technologies must change to prevent unspeakable destruction and future human suffering."

Sir Martin Rees, president of the Royal Society, professor of cosmology and astrophysics, master of Trinity College at the University of Cambridge, and a BAS sponsor, said: "Nuclear weapons still pose the most catastrophic and immediate threat to humanity, but climate change and emerging technologies in the life sciences also have the potential to end civilization as we know it."

Lawrence M. Krauss, professor of physics and astronomy at Case Western Reserve University, and a BAS sponsor, said: "In these dangerous times, scientists have a responsibility to speak truth to power especially if it might provoke actions to reduce threats from the preventable technological dangers currently facing humanity. To do anything else would be negligent."

Ambassador Thomas Pickering, a BAS director and co-chair of the International Crisis Group, said: "Although our current situation is dire, we have the means today to successfully address these global problems. For example, through vigorous diplomacy and international agencies like the International Atomic Energy Agency, we can negotiate and implement agreements that could protect us all from the most destructive technology on Earth--nuclear weapons."

Additional information is available on the Web at http://www.thebulletin.org.