If the proven long-term benefits of smoking cessation are not enough to motivate young adults to stop smoking, a new study shows that 18- to 24-year olds who stop smoking for at least two weeks report substantially fewer respiratory symptoms, especially coughing. The study findings are detailed in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available online.

Karen Calabro, DrPH and Alexander Prokhorov, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, compared self-reported respiratory symptoms among two groups of college students who participated in programs designed to motivate them to stop smoking. One group achieved smoking cessation for two weeks or longer and the other group failed to stop smoking. More than half of the students smoked 5-10 cigarettes a day and had smoked for 1-5 years.

"That the benefit of stopping smoking starts in days to weeks–not years or decades–is important. Now health care providers can counsel young smokers that their breathing can feel better soon after they stop. This can help to motivate young adults to stop smoking before the severe damage is done," says Harold Farber, MD, MSPH, Editor of Pediatric Allergy, Immunology, and Pulmonology and Associate Professor of Pediatrics, Section of Pulmonology, Baylor College of Medicine, Houston, TX.

Sugar should be controlled like alcohol and tobacco to protect public health, according to a team of UCSF researchers, who maintain in a new report that sugar is fueling a global obesity pandemic, contributing to 35 million deaths annually worldwide from non-communicable diseases like diabetes, heart disease and cancer. Non-communicable diseases now pose a greater health burden worldwide than infectious diseases, according to the United Nations. In the United States, 75 percent of health care dollars are spent treating these diseases and their associated disabilities.

In the Feb. 2 issue of Nature, Robert Lustig MD, Laura Schmidt PhD, MSW, MPH, and Claire Brindis, DPH, colleagues at the University of California, San Francisco (UCSF), argue that sugar's potential for abuse, coupled with its toxicity and pervasiveness in the Western diet make it a primary culprit of this worldwide health crisis. This partnership of scientists trained in endocrinology, sociology and public health took a new look at the accumulating scientific evidence on sugar. Such interdisciplinary liaisons underscore the power of academic health sciences institutions like UCSF.

Sugar, they argue, is far from just "empty calories" that make people fat. At the levels consumed by most Americans, sugar changes metabolism, raises blood pressure, critically alters the signaling of hormones and causes significant damage to the liver – the least understood of sugar's damages. These health hazards largely mirror the effects of drinking too much alcohol, which they point out in their commentary is the distillation of sugar.

Worldwide consumption of sugar has tripled during the past 50 years and is viewed as a key cause of the obesity epidemic. But obesity, Lustig, Schmidt and Brindis argue, may just be a marker for the damage caused by the toxic effects of too much sugar. This would help explain why 40 percent of people with metabolic syndrome—the key metabolic changes that lead to diabetes, heart disease and cancer—are not clinically obese. "As long as the public thinks that sugar is just 'empty calories,' we have no chance in solving this," said Lustig, a professor of pediatrics, in the division of endocrinology at the UCSF Benioff Children's Hospital and director of the Weight Assessment for Teen and Child Health (WATCH) Program at UCSF. "There are good calories and bad calories, just as there are good fats and bad fats, good amino acids and bad amino acids, good carbohydrates and bad carbohydrates," Lustig said. "But sugar is toxic beyond its calories."

Limiting the consumption of sugar has challenges beyond educating people about its potential toxicity. "We recognize that there are cultural and celebratory aspects of sugar," said Brindis, director of UCSF's Philip R. Lee Institute for Health Policy Studies. "Changing these patterns is very complicated." According to Brindis, effective interventions can't rely solely on individual change, but instead on environmental and community-wide solutions, similar to what has occurred with alcohol and tobacco, that increase the likelihood of success. The authors argue for society to shift away from high sugar consumption, the public must be better informed about the emerging science on sugar. "There is an enormous gap between what we know from science and what we practice in reality," said Schmidt, professor of health policy at UCSF's Philip R. Lee Institute for Health Policy Studies (IHPS) and co-chair of UCSF's Clinical and Translational Science Institute's (CTSI) Community Engagement and Health Policy Program, which focuses on alcohol and addiction research. "In order to move the health needle, this issue needs to be recognized as a fundamental concern at the global level," she said.

The paper was made possible with funding from UCSF's Clinical and Translational Science Institute, UCSF's National Institutes of Health-funded program that helps accelerate clinical and translational research through interdisciplinary, interprofessional and transdisciplinary work.

Many of the interventions that have reduced alcohol and tobacco consumption can be models for addressing the sugar problem, such as levying special sales taxes, controlling access, and tightening licensing requirements on vending machines and snack bars that sell high sugar products in schools and workplaces. "We're not talking prohibition," Schmidt said. "We're not advocating a major imposition of the government into people's lives. We're talking about gentle ways to make sugar consumption slightly less convenient, thereby moving people away from the concentrated dose. What we want is to actually increase people's choices by making foods that aren't loaded with sugar comparatively easier and cheaper to get."

With growing concern that excessive levels of fructose may pose a great health risk – causing high blood pressure, kidney disease and diabetes – researchers at the University of Colorado School of Medicine, along with their colleagues at the University of Florida, set out to see if two common sweeteners in western diets differ in their effects on the body in the first few hours after ingestion. The study, recently published in the journal Metabolism, took a closer look at high fructose corn syrup (HFCS) and table sugar (sucrose) and was led by Dr MyPhuong Le (now a postdoctoral fellow at the University of Colorado) and Dr Julie Johnson, a Professor of Pharmacogenomics at the University of Florida.

Both HFCS and sucrose have historically been considered to have nearly identical effects on the body. But this study finds that indeed there is a difference between the two. They found that the makeup of the sugars resulted in differences in how much fructose was absorbed into the circulation, and which could have potential impact on one's health. Sucrose is 50 percent fructose and 50 percent glucose that is bonded together as a disaccharide (complex carbohydrate) and HFCS is a mixture of free fructose (55%) and free glucose (45%). It's the difference in fructose amount that appears to create the ill health effects on the body.

Their study was conducted at the University of Florida, where they evaluated 40 men and women who were given 24 ounces of HFCS- or sugar-sweetened soft drinks. Careful measurements showed that the HFCS sweetened soft drinks resulted in significantly higher fructose levels than the sugar-sweetened drinks. Fructose is also known to increase uric acid levels that have been implicated in blood pressure, and the HFCS-sweetened drinks also resulted in a higher uric acid level and a 3 mm Hg greater rise in systolic blood pressure.

Dr Richard Johnson, a coauthor in the study and Chief of the Division of Renal Diseases and Hypertension at the University of Colorado, commented "Although both sweeteners are often considered the same in terms of their biological effects, this study demonstrates that there are subtle differences. Soft drinks containing HFCS result in slightly higher blood levels of fructose than sucrose-sweetened drinks, "said Johnson. "The next step is for new studies to address whether the long-term effects of these two sweeteners are different."

When children have been exposed to family violence, their brains become increasingly "tuned" for processing possible sources of threat, a new study reports. The findings, reported in the December 6th issue of Current Biology, a Cell Press publication, reveal the same pattern of brain activity in these children as seen previously in soldiers exposed to combat. The study is the first to apply functional brain imaging to explore the impact of physical abuse or domestic violence on the emotional development of children, according to the researchers.

"Enhanced reactivity to a biologically salient threat cue such as anger may represent an adaptive response for these children in the short term, helping keep them out of danger," said Eamon McCrory of University College London. "However, it may also constitute an underlying neurobiological risk factor increasing their vulnerability to later mental health problems, and particularly anxiety." Maltreatment is known to be one of the most potent environmental risk factors associated with anxiety and depression. Still, McCrory said, "relatively little is known how such adversity 'gets under the skin' and increases a child's later vulnerability, even into adulthood."

The new study shows that children with documented exposure to violence in the home differ in their brain response to angry versus sad faces. When presented with angry faces, children with a history of abuse show heightened activity in the brain's anterior insula and amygdala, regions involved in detecting threat and anticipating pain. McCrory says the changes don't reflect damage to the brain. Rather, the patterns represent the brain's way of adapting to a challenging or dangerous environment. Still, those shifts may come at the cost of increased vulnerability to later stress.

Although the results may not have immediate practical implications, they are nonetheless critical given that a significant minority of children are exposed to family violence, McCrory says. "This underlines the importance of taking seriously the impact for a child of living in a family characterized by violence. Even if such a child is not showing overt signs of anxiety or depression, these experiences still appear to have a measurable effect at the neural level."

With record levels of student stress reported in a recent UCLA survey, can a simple stress-reducing meditation technique be a viable solution?

A new study published in the Journal of Instructional Psychology found the Transcendental Meditation (TM) technique significantly decreased psychological distress in public school students. The study, conducted with at-risk minority secondary school students, showed a 36 percent reduction in overall psychological distress. Significant decreases were also found in trait anxiety and depressive symptoms.

Rising Stress Levels Affect Emotional and Physical Health
The percentage of students in the UCLA survey reporting good or above-average high school emotional health dropped from 55.3 percent in 2009 to 51.9 percent in 2010. This marks the lowest level within the past 25 years. Dr. Charles Elder, MD, lead author of the TM study, and investigator at Kaiser Permanente Center for Health Research, emphasized the important implications of the findings on reduced stress. "It is vital that we start addressing the high levels of emotional stress being reported by high school and college students. Decreased stress can have a positive impact on mental health, and can also reduce the risk for hypertension, obesity, and diabetes—major risk factors for heart disease," explained Dr. Elder. Educational research has also linked student stress to negative school behavior and poor academic performance.

Promising Findings for Education
"These new findings on reduced stress, along with the recent research on academic achievement gains, hold tremendous promise for public education," said Sanford Nidich, EdD, principal investigator, and professor of education at Maharishi University of Management. "There is a growing body of evidence showing Transcendental Meditation to be an easy to implement, value-added educational program that promotes emotional health and increases academic achievement in at-risk students," said Dr. Nidich.

A total of 106 secondary school students, 87% racial and ethnic minorities, took part in the study. Results showed that over a four-month period, students practicing Transcendental Meditation as part of their schools' Quiet Time program exhibited significant reductions in psychological distress factors compared to controls.

According to James Dierke, 2008 National Association of Secondary School Principals—National Middle School Principal of the Year, "Stress is the number one enemy of public education, especially in inner-city schools. It creates tension, violence, and compromises the cognitive and psychological capacity of students to learn and grow. The TM/Quiet Time program is the most powerful, effective program I have come across in my 39 years as a public school educator for addressing this problem. It is nourishing children and providing them an immensely valuable tool for life. It is saving lives." 

In a study performed on rats, the researchers found that marijuana does not erase the traumatic experience, but only the development of post-trauma symptoms

Cannabinoids (marijuana) administration after experiencing a traumatic event blocks the development of post-traumatic stress disorder (PTSD)-like symptoms in rats, according to a new study conducted at the University of Haifa and published in the journal Neuropsychopharmacology. "We found that there is a 'window of opportunity' during which administering synthetic marijuana helps deal with symptoms simulating PTSD in rats," said Dr. Irit Akirav of the University of Haifa's Department of Psychology, who led the study.

In the study, which Dr. Akirav conducted with research student Eti Ganon-Elazar, the researchers set out to examine how administering cannabinoids (synthetic marijuana) affects the development of PTSD-like symptoms in rats, whose physiological reactions to traumatic and stressful events is similar to human reactions.

In the first part of the study, the researchers exposed a group of rats to extreme stress, and observed that the rats did indeed display symptoms resembling PTSD in humans, such as an enhanced startle reflex, impaired extinction learning, and disruption of the negative feedback cycle of the stress-influenced HPA axis. The rats were then divided into four groups. One was given no marijuana at all; the second was given a marijuana injection two hours after being exposed to a traumatic event; the third group after 24 hours and the fourth group after 48 hours.

A week later, the researchers examined the rats and found that the group that had not been administered marijuana and the group that got the injection 48 hours after experiencing trauma continued to display PTSD symptoms as well as a high level of anxiety. By contrast, the PTSD symptoms disappeared in the rats that were given marijuana 2 or 24 hours after experiencing trauma, even though these rats had also developed a high level of anxiety. "This indicates that the marijuana did not erase the experience of the trauma, but that it specifically prevented the development of post-trauma symptoms in the rat model," said Dr. Akirav, who added that the results suggest there is a particular window of time during which administering marijuana is effective. Because the human life span is significantly longer than that of rats, Dr. Akirav explained, one could assume that this window of time would be longer for humans.

The second stage of the study sought to understand the brain mechanism that is put into operation during the administering of marijuana. To do this, they repeated stage one of the experiment, but after the trauma they injected the synthetic marijuana directly into the amygdala area of the brain, the area known to be responsible for response to trauma. The researchers found that the marijuana blocked development of PTSD symptoms in these cases as well. From this the researchers were able to conclude that the effect of the marijuana is mediated by a CB1 receptor in the amygdala.

NIH-supported population analysis examined records of 5 million California women

Pregnant women who are assaulted by an intimate partner are at increased risk of giving birth to infants of reduced weight, according to a population-level analysis of domestic violence supported by the National Institutes of Health. The study analyzed medical records of more than 5 million pregnant women in California over a 10-year period. Although the results showed a pattern of low-weight births among women who experienced an assault, the study was not designed to establish cause and effect, and so could not prove that violence caused the reduced birth weights. Similarly, the study was not designed to provide a biological explanation for how violence against an expectant mother might cause her child to be of lower birth weight.

Infants born to women who were hospitalized for injuries received from an assault during their pregnancies weighed, on average, 163 grams, or one-third pound, less than did infants born to women who were not hospitalized, the study found. Assaults in the first trimester were associated with the largest decrease in birth weight. Infants born weighing less than 2,500 grams, or 5.5 pounds, are considered low birth weight and have an increased risk of death or of developing several health and developmental disorders. Low birth weight infants also are at greater risk for sudden infant death syndrome (SIDS) as well as breathing problems, cerebral palsy, heart disorders and learning disabilities. The study found that among infants born to mothers who had experienced an assault, about 15 percent weighed less than 2,500 grams at birth. This rate was higher than the rate of low birth weight infants among pregnant women who were hospitalized after a car crash or for other injuries (8 to 10 percent) and more than double the rate among women who were not hospitalized while pregnant (6 percent).

Although women's education level, rates of smoking, and nutritional habits are known to affect birth weight, the study concluded that the lower birth weights seen in the study could not be accounted for by these factors and were most strongly linked to the violence itself. "These findings suggest that violence experienced by pregnant women could put their infants at increased risk for low birth weight and its subsequent health problems," said Rosalind B. King, Ph.D., of the Demographic and Behavioral Sciences Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the NIH institute that funded the study. "It follows that programs to reduce violence against women might have the added benefit of reducing the number of low birth weight infants."

The study was conducted by Anna Aizer, Ph.D., of Brown University, Providence, R.I. Her findings were published online in the Journal of Human Resources. Using data collected between 1991 and 2002, Dr. Aizer compared the birth records in California to the records of pregnant women hospitalized in California as a result of injuries from assault. She found that for every 100,000 women who gave birth in that period, 31 had been hospitalized for an injury from an assault while they were pregnant. Although these data did not distinguish between domestic violence and violence from other types of assault, previous research has shown that 87 percent of pregnant women with injuries were injured by an intimate partner. The overall rate of assaults was 31 per 100,000 women. The study documented higher rates of assault among the poor (49.5 per 100,000), black women (157 per 100,000), and those without a high school education (39 per 100,000).

Dr. Aizer theorized that higher rates of violence among poor women might be a root cause of poor health and poverty that persists in some families from one generation to the next. A connection between violence during pregnancy, adult health, and future earnings is possible because all three factors are linked to low birth weight. Poor women are at greater risk for having low birth weight infants than are other women. In turn, when they reach adulthood, individuals born at low birth weight are at increased risk for such adult health problems as diabetes and heart disease. Also, when they reach adulthood, individuals born at low birth weight infants also earn less than their counterparts who were born at normal birth weight. "The costs of violence against women may be borne not just by the victims but by the next generation as well," said Dr. Aizer. "Given the importance of birth weight in determining adult education and income, these results suggest that the higher levels of violence experienced by poor women may also contribute to the intergenerational persistence of poverty."

Smaller plates, slimmer glasses, linked to weight loss success

Dieters may not need as much willpower as they think, if they make simple changes in their surroundings that can result in eating healthier without a second thought, said a consumer psychologist at the American Psychological Association's 119th Annual Convention.

"Our homes are filled with hidden eating traps," said Brian Wansink, PhD, who presented his findings and strategies for a healthier lifestyle in a plenary address entitled "Modifying the Food Environment: From Mindless Eating to Mindlessly Eating Better."

"Most of us have too much chaos going on in our lives to consciously focus on every bite we eat, and then ask ourselves if we're full. The secret is to change your environment so it works for you rather than against you," Wansink said. Wansink identified several myths about eating behaviors as a way to explain why Americans, on average, have been getting fatter. "People don't think that something as simple as the size of a bowl would influence how much an informed person eats," he said.

However, several studies show exactly that, including Wansink's study of 168 moviegoers, who ate either fresh or stale popcorn from different size containers. People ate 45 percent more fresh popcorn from extra-large containers than large ones and the people who were eating stale popcorn ate 34 percent more from the extra-large buckets than people eating fresh popcorn, according to the study.

"They just don't realize they're doing it," said Wansink. This strategy also applies to what we drink. His research found that people pour about 37 percent more liquid in short, wide glasses than in tall, skinny ones of the same volume. Even a kid's cereal bowl can be a trap, according to Wansink. One study showed children of different weights who were given a 16 ounce bowl were more likely to serve themselves twice as much cereal than children given an 8 ounce bowl.

Another myth, according to Wansink, is that people know when they are full and stop before they overeat. His Food and Brand Lab at Cornell University tested this by designing a "bottomless bowl." They brought in 60 people for a free lunch and gave 22 ounce bowls of soup to half, while the other half unknowingly got 22 ounce bowls that were pressure-fed under the table and slowly refilled. The results: people with bottomless bowls ate 73 percent more than those with normal bowls, yet when asked, they didn't realize they had eaten more. "The lesson is, don't rely on your stomach to tell you when you're full. It can lie," Wansink said.

Simply being aware of such findings can help people make healthier choices, especially those who are already trying to eat healthier foods, according to Wansink. One of his studies showed that people lost up to two pounds a month after making several simple changes in their environment, including:

• eating off salad plates instead of large dinner plates;
• keeping unhealthy foods out of immediate line of sight and moving healthier foods to eye-level in the cupboard and refrigerator;
• eating in the kitchen or dining room, not in front of the television.

"These simple strategies are far more likely to succeed than willpower alone. It's easier to change your environment than to change your mind," Wansink concluded.

A review of more than 160 studies of human and animal subjects has found "clear and compelling evidence" that – all else being equal – happy people tend to live longer and experience better health than their unhappy peers.

The study, in the journal Applied Psychology: Health and Well-Being, is the most comprehensive review so far of the evidence linking happiness to health outcomes. Its lead author, University of Illinois professor emeritus of psychology Ed Diener, who also is a senior scientist for the Gallup Organization, of Princeton, N.J., analyzed long-term studies of human subjects, experimental human and animal trials, and studies that evaluate the health status of people stressed by natural events.

"We reviewed eight different types of studies," Diener said. "And the general conclusion from each type of study is that your subjective well-being – that is, feeling positive about your life, not stressed out, not depressed – contributes to both longevity and better health among healthy populations."

A study that followed nearly 5,000 university students for more than 40 years, for example, found that those who were most pessimistic as students tended to die younger than their peers. An even longer-term study that followed 180 Catholic nuns from early adulthood to old age found that those who wrote positive autobiographies in their early 20s tended to outlive those who wrote more negative accounts of their young lives.

There were a few exceptions, but most of the long-term studies the researchers reviewed found that anxiety, depression, a lack of enjoyment of daily activities and pessimism all are associated with higher rates of disease and a shorter lifespan.

Animal studies also demonstrate a strong link between stress and poor health. Experiments in which animals receive the same care but differ in their stress levels (as a result of an abundance of nest mates in their cages, for example) have found that stressed animals are more susceptible to heart disease, have weaker immune systems and tend to die younger than those living in less crowded conditions.

Laboratory experiments on humans have found that positive moods reduce stress-related hormones, increase immune function and promote the speedy recovery of the heart after exertion. In other studies, marital conflicts and high hostility in married couples were associated with slow wound healing and a poorer immune response.

"I was almost shocked and certainly surprised to see the consistency of the data," Diener said. "All of these different kinds of studies point to the same conclusion: that health and then longevity in turn are influenced by our mood states."

While happiness might not by itself prevent or cure disease, the evidence that positive emotions and enjoyment of life contribute to better health and a longer lifespan is stronger than the data linking obesity to reduced longevity, Diener said.

"Happiness is no magic bullet," he said. "But the evidence is clear and compelling that it changes your odds of getting disease or dying young."

"Although there are a handful of studies that find opposite effects," Diener said, "the overwhelming majority of studies support the conclusion that happiness is associated with health and longevity. Current health recommendations focus on four things: avoid obesity, eat right, don't smoke, and exercise. It may be time to add 'be happy and avoid chronic anger and depression' to the list."

Concordia study finds link between self acceptance, stress hormones and bullying

Young adults who are lesbian, gay or bisexual (LGB) are at far higher risk for severe mental health problems than their heterosexual peers. New research from Concordia University suggests that the stress of being rejected or victimized because of sexual orientation may disrupt hormonal responses in lesbians, gays and bisexuals.

Recently published as a doctoral thesis in clinical psychology, this investigation examined environmental risks and protective factors that counterbalanced them in LGB youth. "Compared to their heterosexual peers, suicide rates are up to 14 times higher among lesbian, gay and bisexual high school and college students," says Michael Benibgui, who led this investigation as part of his PhD thesis at Concordia's Department of Psychology and Centre for Research in Human Development.

"Depression and anxiety are widespread," he continues. "To learn why this occurs, we studied the physiological impact of homophobic social environments on a group of healthy young LGB adults."

Self loathing, stress hormones and bullying linked

The study examined the link between living in a homophobic environment and 'internalized homophobia,' e.g., feeling negatively about oneself because of one's sexual identity as LGB.

Individuals who experienced more LGB-related stress – arguments about sexual identity, bullying or discrimination – had higher internalized homophobia and showed increased production of the stress hormone cortisol compared to peers in more positive environments.

What's more, LGB youth who showed more internalized homophobia and abnormal cortisol activity also experienced increased symptoms of depression, anxiety and suicidal thoughts. "This study is among the first to clearly link the experience of homophobia with abnormal cortisol activity," says Benibgui.

Benibgui says abnormal cortisol activity in LGB youth, combined with the vicious cycle of stress, could be further influenced by a complex set of biological, psychological and social factors. "This study shows a clear relation between abnormal cortisol levels and environmental stressors related to homophobia," he says.

Protective factors of social networks

Benibgui also identified protective factors that can help safeguard mental health in young gays, lesbians and bisexuals. His research confirms that social support from parents and peers have protective effects. "LGB young adults who experienced more homophobic discrimination, yet felt accepted and supported by their peers, showed very few symptoms of depression," he says.

These findings underline the impact – both physical and mental – that homophobia may have on LGB young adults. "The effect on mental health of bullying in schools has received much attention," says Benibgui. "Our study supports the notion that homophobic bullying can lead to physical and mental health problems."

Preventative interventions are needed to protect vulnerable lesbian, gay or bisexual youth, Benibgui stresses, to discourage homophobic and heterosexist behaviors from peers and communities.

Paul Hastings, a former Concordia psychology professor who supervised Benibgui's thesis research, says that this study should push the conversation about the impact of homophobia.

"This study is one part of a much larger and greatly needed dialogue on the impacts that prejudice, discrimination and victimization have on healthy development and well-being in young people," says Dr. Hastings, an international member of the Centre for Research in Human Development and now a professor at the University of California, Davis. "We need to promote acceptance and respect for the diversity of our population – including sexual diversity – at all levels: government, community, schools and homes."

A cold dose of fear lends an edge to the here-and-now — say, when things go bump in the night.

"That edge sounds good. It sounds adaptive. It sounds like perception is enhanced and that it can keep you safe in the face of danger," says Alexander Shackman, a researcher at the University of Wisconsin-Madison. But it sounds like there's also a catch, one that Shackman and his coauthors — including Richard Davidson, UW-Madison psychology and psychiatry professor — described in the Jan. 19 Journal of Neuroscience. "It makes us more sensitive to our external surroundings as a way of learning where or what a threat may be, but interferes with our ability to do more complex thinking," Davidson says.

Faced with the possibility of receiving an unpleasant electric shock, the study's subjects showed enhanced activity in brain circuits responsible for taking in visual information, but a muted signal in circuitry responsible for evaluating that information. Remove the threat of shock (and thus the stress and anxiety) and the effect is reversed: less power for vigilance, more power for strategic decision-making.

The shift in electrical activity in the brain, captured by a dense mesh of sensors placed on the scalp, may be the first biological description of a paradox in experimental psychology.

It has long been known that imminent danger can enhance the ability to detect faint stimuli in the environment, such as the crackle of a leaf signaling the approach of a predator. But it is equally clear that the stress and anxiety aroused by a threat can profoundly disrupt the ability to think clearly and perform more complex "executive" tasks. "In the last few years, theorists have hypothesized that this paradox might reflect several systems working in conjunction: one responsible for the rapid detection of external stimuli, the other responsible for the slower, more reflective evaluation of that incoming information," Shackman says. "Stress upsets the balance of those systems."

In fact, as the senses go into overdrive, they are probably confounding the rest of the brain all the more. "Your ability to do more complex tasks is disrupted just as the amount of information you're receiving through your eyes and ears is enhanced," Shackman says. "You're having trouble focusing on the information coming in, but your brain is taking in more and more potentially irrelevant information. You can have a viscous feedback loop, a sort of double-whammy effect."

The resulting confusion favors quick, reflexive actions, the "survival instincts" often mentioned by trauma survivors — Noise? RUN! — in a way that was likely adaptive in the dangerous environments in which the ancestors to modern humans evolved. "In our evolutionary past, the dangers we faced were really survival-threatening," Davidson says. "That's not so much the case now. Because of the nature of our brains, we can use our neural capacity to create our own internal danger. We can worry about the future and ruminate about the past."

Either one is likely to present a real hurdle to effective decision-making under stress. "This is part of a growing body of evidence showing that stress does have important consequences for the brain, not just something that arouses the body — tension in your muscles or butterflies in the stomach," says Davidson, who studies the effects of meditation as director of UW-Madison's Center for Investigating Healthy minds. "One of the things we would expect is that if we use an antidote like systematic meditation training to learn to control stress it would not just calm the body, but improve our ability to engage in complex analytical activity," he says.

Two UA studies have found that hoarding friends doesn't necessarily diminish forlorn feelings and that loneliness is a matter of perception

Hoarding friends on Facebook – or followers on Twitter – won't do much to stave off loneliness if those relationships lack any kind of strong connection, new research finds. Two newly published University of Arizona studies suggest that superficial relationships can not only result in feelings of detachment, but also contribute to certain health-related problems.

"There is an association between social networks and health but the precise mechanism is not understood," said Stacey Passalacqua, who recently earned her UA doctorate in interpersonal and health communication with a minor in psychology. Passalacqua and Chris Segrin, the UA communication department head and lead author on the papers, decided to study individual perceptions of stress and social support to understand ways loneliness may be linked to health.

In their study of 265 adults ages 19 to 85, Segrin and Passalacqua found that stress serves a crucial function for those who reported being lonely. They found that lonely people were prone to have fewer close connections, were less apt to manage daily stressors well and tended not to keep up on their health. Also, lonely people did not get adequate sleep.

Segrin noted that age did not predict whether a person would be lonely and living away from close friends and family did not have a negative effect. Also, having relationships mediated by digital modes is not necessarily problematic, though relationships well-established prior to the distance were likely the strongest.

Being partnered did not shield a person from feelings of loneliness, Segrin added. Instead, having close friends and family members appeared to be more important. "The mere presence of a relationship is not always something that is going to lead to you feeling satisfied and supported," he said.

Another curious conclusion: The team found that, above all, loneliness is a matter of perception. "Loneliness is the discrepancy between your achieved and desired level of social contact, and that has important implications," Segrin said. "The portrait of a lonely person is very difficult to paint because what is really important is what is in your head."

So people can experience the same stressors – maybe the car breaks down, or a checking account overdraws, or maybe a relationship is not going well and someone just needs to vent – and have entirely different responses. It is no wonder, then, that certain people with large social networks also express feelings of loneliness. When it comes to relationships, quality, not quantity, is the decisive factor, Passalacqua said. "There are so many people we have in our day-to-day interactions," she said. "But the absence of close family members and close friends is something that should be taken seriously. Sometimes we don't realize how important these close relationships are to our health."

The findings were published in a co-authored article, "Functions of Loneliness, Social Support, Health Behaviors, and Stress in Association With Poor Health," in a June issue of Health Communication. Segrin also collaborated with Tricia Domschke, doctoral degree candidate in communication, on another study to look further into such details. The co-authored article, "Social Support, Loneliness, Recuperative Processes and their Direct and Indirect Effects on Health," has been accepted for publication also in Health Communication. Segrin and Domschke found that lonely people did not enjoy leisure activities or get regenerate effects from sleep at a comparable level as others did. So when it came to taking a vacation, getting a good night's sleep, or going for a swim, lonely people did not get as much of a recharge.

What both studies suggest is that people need not only to take better care of themselves, but learn to nurture the relationships. "We know that chronic stressors are very damaging to the human system," Passalacqua said. "Perceptions are all it takes, and when you experience stress, it has a physiological effect on the body," she added. "The mind has such a powerful effect on the body and, really, our perceptions are going to shape our world."

There is no evidence to support psychological debriefing in schools after traumatic events such as violence, suicides and accidental death, which runs counter to current practice in some Canadian school jurisdictions, according to a commentary http://www.cmaj.ca/embargo/cmaj091621.pdf in CMAJ (Canadian Medical Association Journal) www.cmaj.ca .

Recent systematic reviews indicate that psychological debriefing of adults does not prevent post-traumatic stress disorder and it may even increase the risk of this disorder. While there is little research on the effectiveness and safety of these interventions in schools, "the evidence clearly points to the ineffectiveness of these interventions in preventing post-traumatic stress disorder or any other psychiatric disorder in adults," write Magdalena Szumilas of the Sun Life Financial Chair in Adolescent Mental Health Team, Dalhousie University and coauthors.

Two programs, based on the empirically-supported principles of engendering feelings of safety, calmness, sense of self and community efficacy, connectedness and hope, show promise of effectiveness. Providing Psychological First Aid immediately after an incident and providing cognitive behavioural support for students with persistent distress weeks after a school trauma has ended may be helpful.

They urge that psychological debriefing not be performed after traumatic incidents in schools, and that more research is needed to assess psychological and mental health interventions prior to implementation in schools.

Patients with coronary heart disease who practiced the stress-reducing Transcendental Meditation® technique had nearly 50 percent lower rates of heart attack, stroke, and death compared to nonmeditating controls, according to the results of a first-ever study presented during the annual meeting of the American Heart Association in Orlando, Fla., on 16 Nov. 2009.

The trial was sponsored by a $3.8 million grant from the National Institutes of Health–National Heart, Lung, and Blood Institute, and was conducted at The Medical College of Wisconsin in Milwaukee in collaboration with the Institute for Natural Medicine and Prevention at Maharishi University of Management in Fairfield, Iowa.

The nine-year, randomized control trial followed 201 African American men and women, average age 59 years, with narrowing of arteries in their hearts who were randomly assigned to either practice the stress-reducing Transcendental Meditation technique or to participate in a control group which received health education classes in traditional risk factors, including dietary modification and exercise. All participants continued standard medications and other usual medical care.

The study found:

• A 47% reduction in the combination of death, heart attacks, and strokes in the participants
  
• Clinically significant (5 mm Hg average) reduction in blood pressure associated with decrease in clinical events
  
• Significant reductions in psychological stress in the high-stress subgroup

According to Robert Schneider, M.D., FACC, lead author and director of the Center for Natural Medicine and Prevention, "Previous research on Transcendental Meditation has shown reductions in blood pressure, psychological stress, and other risk factors for heart disease, irrespective of ethnicity. But this is the first controlled clinical trial to show that long-term practice of this particular stress reduction program reduces the incidence of clinical cardiovascular events, that is heart attacks, strokes and mortality."

"This study is an example of the contribution of a lifestyle intervention—stress management—to the prevention of cardiovascular disease in high-risk patients," said Theodore Kotchen, M.D., co-author of the study, professor of medicine, and associate dean for clinical research at the Medical College. Other investigators at the Milwaukee site included Drs. Jane Kotchen and Clarence Grim.

Dr. Schneider said that the effect of Transcendental Meditation in the trial was like adding a class of newly discovered medications for the prevention of heart disease. "In this case, the new medications are derived from the body's own internal pharmacy stimulated by the Transcendental Meditation practice," he said.

'The results of our research should encourage psychiatric investigation into using cannabinoids in post-traumatic stress patients,' says researcher Dr. Irit Akirav of the University of Haifa

Use of cannabinoids (marijuana) could assist in the treatment of post-traumatic stress disorder patients. This is exposed in a recent study carried out at the Learning and Memory Lab in the University of Haifa's Department of Psychology. The study, carried out by research student Eti Ganon-Elazar under the supervision of Dr. Irit Akirav, was published in the prestigious Journal of Neuroscience.

In most cases, the result of experiencing a traumatic event – a car accident or terror attack – is the appearance of medical and psychological symptoms that affect various functions, but which pass. However, some 10%-30% of people who experience a traumatic event develop post-traumatic stress disorder, a condition in which the patient continues to suffer stress symptoms for months and even years after the traumatic event. Symptoms include reawakened trauma, avoidance of anything that could recall the trauma, and psychological and physiological disturbances. One of the problems in the course of treating trauma patients is that a person is frequently exposed to additional stress, which hinders the patient's overcoming the trauma.

The present study, carried out by Dr. Akirav and research student Eti Ganon-Elazar, aimed to examine the efficiency of cannabinoids as a medical treatment for coping with post-traumatic stress. The researchers used a synthetic form of marijuana, which has similar properties to the natural plant, and they chose to use a rat model, which presents similar physiological responses to stress to that of humans.

The first stage of the research examined how long it took for the rats to overcome a traumatic experience, without any intervention. A cell colored white on one side and black on the other was prepared. The rats were placed in the white area, and as soon as they moved over to the black area, which they prefer, they received a light electric shock. Each day they were brought to the cell and placed back in the white area. Immediately following exposure to the traumatic experience, the rats would not move to the black area voluntarily, but a few days later after not receiving further electric shocks in the black area, they learned that it is safe again and moved there without hesitation.

Next, the researchers introduced an element of stress. A second group of rats were placed on a small, elevated platform after receiving the electric shock, which added stress to the traumatic experience. These rats abstained from returning to the black area in the cell for much longer, which shows that the exposure to additional stress does indeed hinder the process of overcoming trauma.

The third stage of the research examined yet another group of rats. These were exposed to the traumatic and additional stress events, but just before being elevated on the platform received an injection of synthetic marijuana in the amygdala area of the brain – a specific area known to be connected to emotive memory. These rats agreed to enter the black area after the same amount of time as the first group – showing that the synthetic marijuana cancelled out the symptoms of stress. Refining the results of this study, the researchers then administered marijuana injections at different points in time on additional groups of rats, and found that regardless of when exactly the injection was administered, it prevented the surfacing of stress symptoms.

Dr. Akirav and Ganon-Elazar also examined hormonal changes in the course of the experiment and found that synthetic marijuana prevents increased release of the stress hormone that the body produces in response to stress.

According to Dr. Akirav, the results of this study show that cannabinoids can play an important role in stress-related disorders. "The results of our research should encourage psychiatric investigation into the use of cannabinoids in post-traumatic stress patients," she concludes.

We can challenge our brains or our bodies, but not both, says study

Have you ever sat down to work on a crossword puzzle only to find that afterwards you haven't the energy to exercise? Or have you come home from a rough day at the office with no energy to go for a run?

A new study, published today in Psychology and Health, reveals that if you use your willpower to do one task, it depletes you of the willpower to do an entirely different task. "Cognitive tasks, as well as emotional tasks such as regulating your emotions, can deplete your self-regulatory capacity to exercise," says Kathleen Martin Ginis, associate professor of kinesiology at McMaster University, and lead author of the study.

Martin Ginis and her colleague Steven Bray used a Stroop test to deplete the self-regulatory capacity of volunteers in the study. (A Stroop test consists of words associated with colors but printed in a different color. For example, "red" is printed in blue ink.) Subjects were asked to say the color on the screen, trying to resist the temptation to blurt out the printed word instead of the color itself. "After we used this cognitive task to deplete participants' self-regulatory capacity, they didn't exercise as hard as participants who had not performed the task. The more people "dogged it" after the cognitive task, the more likely they were to skip their exercise sessions over the next 8 weeks. "You only have so much willpower."

Still, she doesn't see that as an excuse to let people loaf on the sofa. "There are strategies to help people rejuvenate after their self-regulation is depleted," she says. "Listening to music can help; and we also found that if you make specific plans to exercise—in other words, making a commitment to go for a walk at 7 p.m. every evening—then that had a high rate of success." She says that by constantly challenging yourself to resist a piece of chocolate cake, or to force yourself to study an extra half-hour each night, then you can actually increase your self-regulatory capacity. "Willpower is like a muscle: it needs to be challenged to build itself," she says.

Whether it's getting a cold during exam time or feeling run-down after a big meeting, we've all experienced feeling sick following a particularly stressful time at work or school. Is this merely coincidence, or is it possible that stress can actually make us sick? In a new report in Perspectives on Psychological Science, a journal of the Association for Psychological Science, psychologist Janice K. Kiecolt-Glaser from the Ohio State University College of Medicine reviews research investigating how stress can wreak havoc on our bodies and provides some suggestions to further our understanding of this connection.

The field of psychoneuroimmunology (PNI) investigates how stress and negative emotions (such as depression and anxiety) affect our health. Over the past 30 years, researchers in this field have uncovered a number of ways that stress adversely affects our health, and specifically, how stress can damage our immune system. Numerous studies have shown that stressed individuals show weaker immune responses to vaccines, and as Kiecolt-Glaser observes, "The evidence that stress and distress impair vaccine responses has obvious public health relevance because infectious diseases can be so deadly." Stress and depression have been shown to increase the risk of getting infections and also result in delayed wound healing.

Inflammation is the body's way of removing harmful stimuli and also starts the process of healing, via release of a variety of chemicals known as proinflammatory cytokines (e.g., interleukin-6). However, too much inflammation can be damaging and has been implicated in the development of many age-related diseases, including Alzheimer's Disease, Parkinson's disease, arthritis, and Type II diabetes. Negative emotions and psychological stressors increase the production of proinflammatory cytokines. A recent study revealed that men and women who serve as caregivers to spouses with dementia (and thus are under constant stress) have a four times larger annual rate of increase in serum interleukin-6 levels compared to individuals without caregiving responsibilities.

What's more, the changes in interleukin-6 levels among former caregivers did not differ from current caregivers, even following the death of the impaired spouse, indicating that chronic stress may cause the immune system to age quickly. Kiecolt-Glaser notes, "These stress-related changes in inflammation provide evidence of one mechanism through which stressors may accelerate risk of a host of age-related diseases."

Kiecolt-Glaser argues that our environment should be taken into account when studying the link between stress and our health. For instance, diet may modify interactions between psychological and immunological responses: Omega-3 fatty acids (found in fish and walnuts) can reduce production of some proinflammtory chemicals and increasing levels of omega-3 fatty acids may result in positive effects on mood and the immune system. Environmental toxins (such as pesticides and air pollutants) can have extremely negative effects on the immune system and these effects may be intensified in stressed individuals, increasing their risk for developing allergies, asthma, and viral infections.

Kiecolt-Glaser suggests that to most effectively tackle the questions raised by recent PNI research, cross-discipline training needs to be emphasized for students. Psychology students who gain a strong foundation in areas such as biology and physiology will be able to enter into powerful collaborations with scientists conducting immunology research. Kiecolt-Glaser concludes that the questions answered by these collaborations will advance PNI as well as psychology in general.

"By providing key data on how stressful events and the emotions they evoke get translated into health," she suggested, "psychology will assume a more dominant role in the health sciences, in health promotion, and in public health policy."

Women experiencing physical abuse from intimate partners spent 42 percent more on health care per year than non-abused women, according to a long-term study of more than 3,000 women. And the costs don't end when the abuse does. The study revealed that women who suffered physical abuse five or more years earlier still spent 19 percent more per year on health care than women who were never abused. "Along with all the physical and emotional pain it causes, domestic violence also comes with a substantial financial price," said Amy Bonomi, co-author of the study and associate professor of human development and family science at Ohio State University.

The study is the largest to date to examine health care costs and utilization based on the timing and type of domestic violence that women suffer, Bonomi said. The study, co-authored with researchers from the Group Health Cooperative and the University of Washington in Seattle, was published online this week in the journal Health Services Research. It will appear in an upcoming print edition.

The research examined data from 3,333 randomly selected women who belonged to Group Health, a health care system in the Pacific Northwest. Women in the study were surveyed about whether they experienced any physical or emotional abuse from intimate partners and if so, when it occurred. Researchers then studied patterns of health care use and costs by the women over an 11-year period, from 1992 through 2002.

"We were able to track health care costs for quite a long time, giving us a good picture of how much domestic violence is actually costing our health care system," Bonomi said. Women experiencing ongoing physical abuse had the highest health care costs -- 42 percent higher than non-abused women. "It's likely that these women need more health care because they are seeking care for immediate injuries and associated health problems," Bonomi said. Women who had been physically abused within the last five years, but not currently, had 24 percent higher yearly health costs. Abuse that occurred more than five years ago resulted in 19 percent higher costs.

The study separately examined women who experienced psychological abuse, which included verbal threats and chronic controlling behavior. Those suffering psychological abuse within the past five years, but not currently, had yearly health care costs that were 33 percent higher than those of non-abused women. "It's possible that it takes additional time for women with psychological abuse to seek care for their experiences," Bonomi said.

Another striking finding was that all abused women, whether they experienced physical or psychological abuse, used significantly more mental health services than non-abused women, Bonomi said. Women suffering ongoing physical abuse were about 2.5 times more likely to visit a mental health provider in the past year than were non-abused women. The rate for psychologically abused women was two times higher. "This lends support to the idea that mental health providers should always ask women about their abuse history when they first come in for treatment," Bonomi said.

But mental health was just one of several areas in which abused women used more services. Physically abused women used significantly more primary care, pharmacy, specialty care, laboratory and radiology services. For psychologically abused women, more services were needed in specialty care, pharmacy, and radiology.

Group Health, the health care system whose members were surveyed for the study, provides health and insurance services to more than 500,000 people in the Pacific Northwest.

Before flying off the handle the next time someone cuts you off in traffic, consider the latest research from Yale School of Medicine researchers that links changes brought on by anger or other strong emotions to future arrhythmias and sudden cardiac arrests, which are blamed for 400,000 deaths annually.

The study—led by Rachel Lampert, M.D., associate professor of medicine at Yale School of Medicine, and published in the Journal of the American College of Cardiology—deepens our understanding of how anger and other types of mental stress can trigger potentially lethal ventricular arrhythmias.

Lampert and her team studied 62 patients with implantable cardioverter-defibrillators (ICDs) and enlarged hearts. They were monitored three months after the ICD was implanted and then given a mental stress test requiring them to recall a stressful situation that angered them.

Lampert and her team sought to discover whether T-wave alternans (TWA), which monitor electrical instability in the heart induced by anger, would predict future ventricular arrhythmias. The team found that those in the group with more anger-induced electrical instability were more likely to experience arrhythmias one year after the study than those in the control group.

"Further studies are needed to determine whether there is a role for therapies which may reduce anger and the body's response to stress, thereby preventing arrhythmias in those at risk," said Lampert.

Lampert's work builds on past research linking strong emotion to sudden cardiac death. It has been found that devastating disasters, such as earthquakes, are linked to sudden death.

Data from a new study suggests that individuals who engage in compassion meditation may benefit by reductions in inflammatory and behavioral responses to stress that have been linked to depression and a number of medical illnesses. The study's findings are published online at www.sciencedirect.com and in the medical journal Psychoneuroendocrinology.

"While much attention has been paid to meditation practices that emphasize calming the mind, improving focused attention or developing mindfulness, less is known about meditation practices designed to specifically foster compassion," says Geshe Lobsang Tenzin Negi, PhD, who designed and taught the meditation program used in the study. Negi is senior lecturer in the Department of Religion, the co-director of Emory Collaborative for Contemplative Studies and president and spiritual director of Drepung Loseling Monastery, Inc.

This study focused on the effect of compassion meditation on inflammatory, neuroendocrine and behavioral responses to psychosocial stress, and evaluated the degree to which engagement in meditation practice influenced stress reactivity. "Our findings suggest that meditation practices designed to foster compassion may impact physiological pathways that are modulated by stress and are relevant to disease," explains Charles L. Raison, MD, clinical director of the Mind-Body Program, Emory University's Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, and a lead author on the study.

Sixty-one healthy college students between the ages of 17 and19 participated in the study. Half the participants were randomized to receive six weeks of compassion meditation training and half were randomized to a health discussion control group. Although secular in presentation, the compassion meditation program was based on a thousand-year-old Tibetan Buddhist mind-training practice called "lojong" in Tibetan. Lojong practices utilize a cognitive, analytic approach to challenge an individual's unexamined thoughts and emotions toward other people, with the long-term goal of developing altruistic emotions and behavior towards all people. Each meditation class session combined teaching, discussion and meditation practice.

The control group attended classes designed by study investigators on topics relevant to the mental and physical health of college students such as stress management, drug abuse and eating disorders. In addition, a variety of student participation activities were employed such as mock debates and role-playing. Both groups were required to participate in 12 hours of classes across the study period. Meditators were provided with a meditation compact disc for practice at home. Homework for the control group was a weekly self-improvement paper.

After the study interventions were finished, the students participated in a laboratory stress test designed to investigate how the body's inflammatory and neuroendocrine systems respond to psychosocial stress. No differences were seen between students randomized to compassion meditation and the control group, but within the meditation group there was a strong relationship between the time spent practicing meditation and reductions in inflammation and emotional distress in response to the stressor. Consistent with this, when the meditation group was divided into high and low practice groups, participants in the high practice group showed reductions in inflammation and distress in response to the stressor when compared to the low practice group and the control group.

"It will require conducting stress tests before and after meditation training in order to conclusively show it was the practice of compassion meditation that resulted in reduced stress responses," says study co-author Thaddeus W.W. Pace, PhD, assistant professor, Department of Psychiatry and Behavioral Sciences at Emory. "But these initial results are quite exciting," says Pace. "If practicing compassion meditation does reduce inflammatory responses to stress it might offer real promise as a means of preventing many conditions associated with stress and with inflammation including major depression, heart disease and diabetes." Raison concurs. "Based on the promising findings from this study we are planning to offer compassion meditation classes to patients at Emory Winship Cancer Institute, and have partnered with the Emory Predictive Health Institute to study potential long term effects of compassion meditation on health and well-being," says Raison.

A link between reduced levels of the 'stress hormone' cortisol and antisocial behaviour in male adolescents has been discovered by a research team at the University of Cambridge.

Levels of cortisol in the body usually increase when people undergo a stressful experience, such as public speaking, sitting an exam, or having surgery. It enhances memory formation and is thought to make people behave more cautiously and to help them regulate their emotions, particularly their temper and violent impulses.

The new research, funded by the Wellcome Trust, shows that adolescents with severe antisocial behaviour do not exhibit the same increase in cortisol levels when under stress as those without antisocial behaviour. These findings suggest that antisocial behaviour, at least in some cases, may be seen as a form of mental illness that is linked to physiological symptoms (involving a chemical imbalance of cortisol in the brain and body).

The scientists, led by Dr Graeme Fairchild and Professor Ian Goodyer, recruited participants for the study from schools, pupil referral units, and the Youth Offending Service. Samples of saliva were collected over several days from the subjects in a non-stressful environment to measure levels of the hormone under resting conditions. The young men then took part in a stressful experiment that was designed to induce frustration. Samples of saliva were taken immediately before, during and after the experiment to track how cortisol changed during stress.

The differences between participants with severe antisocial behaviour and those without were most marked under stressful conditions. While the average adolescents showed large increases in the amount of cortisol during the frustrating situation, cortisol levels actually went down in those with severe antisocial behaviour.

These results suggest that antisocial behaviour may be more biologically-based than previously considered, just as some individuals are more vulnerable to depression or anxiety due to their biological make-up. Dr Fairchild said, "If we can figure out precisely what underlies the inability to show a normal stress response, we may be able to design new treatments for severe behaviour problems. We may also be able create targeted interventions for those at higher risk. "A possible treatment for this disorder offers the chance to improve the lives of both the adolescents who are afflicted and the communities in which they live."

Workplace bullying, such as belittling comments, persistent criticism of work and withholding resources, appears to inflict more harm on employees than sexual harassment, say researchers who presented their findings at a conference today. “As sexual harassment becomes less acceptable in society, organizations may be more attuned to helping victims, who may therefore find it easier to cope,” said lead author M. Sandy Hershcovis, PhD, of the University of Manitoba. “In contrast, non-violent forms of workplace aggression such as incivility and bullying are not illegal, leaving victims to fend for themselves.” This finding was presented at the Seventh International Conference on Work, Stress and Health, co-sponsored by the American Psychological Association, the National Institute of Occupational Safety and Health and the Society for Occupational Health Psychology.

Hershcovis and co-author Julian Barling, PhD, of Queen’s University in Ontario, Canada, reviewed 110 studies conducted over 21 years that compared the consequences of employees’ experience of sexual harassment and workplace aggression. Specifically, the authors looked at the effect on job, co-worker and supervisor satisfaction, workers’ stress, anger and anxiety levels as well as workers’ mental and physical health. Job turnover and emotional ties to the job were also compared. The authors distinguished among different forms of workplace aggression. Incivility included rudeness and discourteous verbal and non-verbal behaviors. Bullying included persistently criticizing employees’ work; yelling; repeatedly reminding employees of mistakes; spreading gossip or lies; ignoring or excluding workers; and insulting employees’ habits, attitudes or private life. Interpersonal conflict included behaviors that involved hostility, verbal aggression and angry exchanges.

Both bullying and sexual harassment can create negative work environments and unhealthy consequences for employees, but the researchers found that workplace aggression has more severe consequences. Employees who experienced bullying, incivility or interpersonal conflict were more likely to quit their jobs, have lower well-being, be less satisfied with their jobs and have less satisfying relations with their bosses than employees who were sexually harassed, the researchers found. Furthermore, bullied employees reported more job stress, less job commitment and higher levels of anger and anxiety. No differences were found between employees experiencing either type of mistreatment on how satisfied they were with their co-workers or with their work. “Bullying is often more subtle, and may include behaviors that do not appear obvious to others,” said Hershcovis. “For instance, how does an employee report to their boss that they have been excluded from lunch? Or that they are being ignored by a coworker? The insidious nature of these behaviors makes them difficult to deal with and sanction.”

From a total of 128 samples that were used, 46 included subjects who experienced sexual harassment, 86 experienced workplace aggression and six experienced both. Sample sizes ranged from 1,491 to 53,470 people. Participants ranged from 18 to 65 years old. The work aggression samples included both men and women. The sexual harassment samples examined primarily women because, Hershcovis said, past research has shown that men interpret and respond differently to the behaviors that women perceive as sexual harassment.

Exercise has a similar effect to antidepressants on depression. This has been shown by previous research. Now Astrid Bjørnebekk at Karolinska Institutet has explained how this can happen: exercise stimulates the production of new brain cells.

In a series of scientific reports, she has searched for the underlying biological mechanisms that explain why exercise can be a form of therapy for depression and has also compared it with pharmacological treatment with an SSRI drug.

The experiment studies were conducted on rats. The results show that both exercise and antidepressants increase the formation of new cells in an area of the brain that is important to memory and learning. Astrid Bjørnebekk's studies confirm previous research results, and she proposes a model to explain how exercise can have an antidepressant effect in mild to moderately severe depression. Her study also shows that exercise is a very good complement to medicines.

"What is interesting is that the effect of antidepressant therapy can be greatly strengthened by external environmental factors," she says.

Previous studies have shown that drug abusers have lowered levels of the dopamine D2 receptor in the brain's reward system. It has been speculated that this may be of significance to the depressive symptoms drug abusers often suffer from. These rat studies show that genetic factors may influence how external environmental factors can regulate levels of the dopamine D2 receptor in the brain.

"Different individuals may have differing sensitivity to how stress lowers dopamine D2 receptor levels, for example. This might be significant in explaining why certain individuals develop depression more readily than others," she says.

Washington — Young adults with a short temper or mean disposition also tend to have compromised lung function, says a recent study published in the journal Health Psychology, by the American Psychological Association (APA). This occurred even when asthma and smoking were ruled out as possible causes of lung dysfunction.

In a study of 4,629 Black and White 18-30 year olds from four metropolitan areas (sampled from the Coronary Artery Risk Development in (Young) Adults Study cohort (CARDIA), psychologists examined whether the tendency to be hostile went along with having decreased lung function in otherwise healthy young adults. The results indicated that the more hostile one’s personality—characterized by aggression or anger, for example—the lower levels one’s of lung function even after controlling for age, height, socioeconomic status, smoking status and presence of asthma.

People with higher levels of general frustration predicted statistically significant reductions in pulmonary function for Black women, White women, and Black men. The only marginally strong finding occurred among the White men sampled. The authors speculate that people in lower status roles, Black women, White women, and Black men, who display hostility (and may be pushing against social expectations), elicit stronger social consequences than White men, resulting in higher levels of internalized stress that can make them sick. Further research is required to rule out if environmental toxins such as air pollution may contribute to both higher hostility and lower lung function.

Hostility was measured using the Cook-Medley Questionnaire which is derived from the items on the Minnesota Multiphasic Personality Inventory. Pulmonary function was measured while participants were standing and wearing a nose clip, blowing into a machine to measure their lung capacity, which can indicate upper airway obstruction.

“Recent research demonstrates that greater hostility predicts lung function decline in older men. This is the first study of young adults to offer a detailed examination of the inverse link between hostility and pulmonary function,” states lead author and psychologist Benita Jackson PhD MPH, Smith College. “It’s remarkable to see reductions in lung function during a time of life we think of as healthy for most people. Right now, we can’t say if having a hostile personality causes lung function decline, though we now know that these things happen together. More research is needed to establish whether hostility is associated with change in pulmonary function during young adulthood.” This research has implications for future research exploring the possible influence of social status on personality functioning and pulmonary health.

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Article: Does Harboring Hostility Hurt" Associations Between Hostility and Pulmonary Function in the Coronary Artery Risk Development in (Young) Adults (CARDIA) Study, Journal of Health Psychology, Vol. 26 No. 3

Full text of the article is available at http://www.apa.org/journals/releases/hea263333.pdf

Smoking reduction may lead to unexpected quitting
In a review article in the December Nicotine and Tobacco Research, researchers at the University of Vermont have found an unexpected, effective alternative to motivate smokers to quit smoking – cutting back. According to the qualitative review of 19 studies on smoking reduction in individuals who did not want to quit, this method, typically coupled with the use of nicotine replacement products, led to an increase in quitting in 16 of the studies.

"Cutting back is approved as a method of quitting in several European countries, but not in the United States," said lead author John Hughes, M.D., a professor of psychiatry at the University of Vermont College of Medicine. "Our review contradicts the commonly held belief that quitting requires stopping abruptly and provides evidence that smokers can quit successfully by reducing the amount of cigarettes smoked. Furthermore, our review indicates cutting back is often a great way to start changing smoking that can lead to eventual quitting."

Hughes's report is the largest review of smoking reduction studies published to date. Among the 19 studies reviewed (many of which were randomized, placebo-controlled trials), the two considered the most important involved randomized, controlled trials that assigned smokers to either reduce or not reduce. Both of these studies found that smoking reduction leads to more cessation. Also, in three studies, the effect of reduction was found to be similar to the effect of providing smoking cessation advice. Based on this finding, Hughes suggests that clinicians try recommending reduction for smokers who have not responded to repeated cessation advice.

Hughes and colleague Matthew Carpenter warn that smokers do need to understand that there is no good evidence that cutting back alone decreases smoking-related health risks and thus clinicians should promote reduction only as a step towards eventual cessation to their patients.

Researchers from the University of Cincinnati have found that eating or drinking sweets may decrease the production of the stress-related hormone glucocorticoid—which has been linked to obesity and decreased immune response.

“Glucocorticoids are produced when psychological or physical stressors activate a part of the brain called the ‘stress axis,’” said Yvonne Ulrich-Lai, PhD, a postdoctoral fellow in the department of psychiatry. “These hormones help an individual survive and recover from stress, but have been linked to increased abdominal obesity and decreased immune function when produced in large amounts.

“Finding another way to affect the body’s response to stress and limit glucocorticoid production could alleviate some of these dangerous health effects.”

The laboratory findings were presented during a poster session Tuesday, Nov. 15, at the annual Society for Neuroscience meeting in Washington, D.C.

Dr. Ulrich-Lai and a team of researchers from the department of psychiatry showed that when laboratory rats chose to eat or drink sweet snacks their bodies produced lower levels of glucocorticoid.

She said that sweets—especially those made from sugar, not artificial sweetener—might do the trick.

"The sweets we are talking about are not the low-calorie, sugar-substitute variety,” said Dr. Ulrich-Lai. “We actually found that sugar snacks, not artificially sweetened snacks, are better ‘self-medications’ for the two most common types of stress—psychological and physical.”

Psychological stress could involve things such as public speaking, being threatened, or coping with the death of a loved one. Examples of physical stress are injury, illness, or prolonged exposure to cold.

During the study, researchers gave adult male rats free access to food and water and also offered them a small amount of sugar drink, artificially sweetened drink, or water twice a day. After two weeks, the rats were given a physical and psychological stress challenge. Following both types of stress, rats that had consumed the sugar drink had lower glucocorticoid levels than those that drank the water. Those drinking the artificially sweetened drink showed only slightly reduced glucocorticoid levels.

Dr. Ulrich-Lai noted that although her team was not studying the health effects of the sweetened drinks, they did not notice a body-weight increase in the rats consuming the sugar drinks.

James Herman, PhD, co-author, professor and stress neurobiologist in the department of psychiatry, said the next step will be to determine how these sweetened drinks are decreasing glucocorticoid production.

“We need to find out if there are certain parts of the brain that control the response to stress, then determine if the function of these brain regions are changed by sugar snacking,” he said.

Co-authors also included Dennis Choi and Michelle Ostrander, PhD, both of UC’s psychiatry department.

University of Cincinnati Medical Center News
15 November 2005

Commuting is never fun, and is almost always stressful, in part because we often have no control over what happens to us. But everyday we get in our car, or board the train or bus, and make our way to work, having become accustomed to this stress, not realizing that this stress may have a measurable affect on our brain.

Although we do not yet know if this is the case for humans, new research in rats from the laboratory of Rockefeller University’s Bruce McEwen, Ph.D., shows that chronic, uncontrollable stress of repeated confinement leads to gradual changes in brain structure over weeks. Yet, even a single acute stress of putting a rat in a tube where it cannot move freely also causes a structural change in the brain, not immediately but over days, along with higher levels of anxiety. These results may help scientists understand what is happening in the human brain during post-traumatic stress disorder and other anxiety disorders and depressive illness.

In earlier studies, McEwen and colleagues had looked at changes in the hippocampus and the prefrontal cortex, areas of the brain that respond to repeated, confinement stress and which are important in memory storage and retrieval. Turning to a different area of the brain called the amygdala, which is thought to play a role in fear and anxiety memories, they wanted to see if it too was involved in processing stressful experiences. Indeed they found that repeated stress increased anxiety as well as a form of aggression.

“Understanding how the whole nervous system functions, how the different areas of the brain interact, is vital to understanding the neurological basis of depressive illness and anxiety disorders,” says McEwen, who is the Alfred E. Mirsky Professor and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at Rockefeller. “And we knew of some evidence that the neurons in the amygdala are more active in depression and anxiety disorders.”

“The new paper, conducted in collaboration with Dr. Sumantra Chattarji’s laboratory in Bangalore, India, and MIT, shows that even a single stressful event in these animals can have a measurable and delayed influence on the architecture of their brains, and on their behavior,” adds McEwen. “We would like to think that these findings might become relevant in understanding conditions like post-traumatic stress disorder and depression.”

The follow-up of this paper is under investigation in collaborative studies with investigators at the Weill Medical College of Cornell University, Mt. Sinai School of Medicine and New York University under a National Institute of Mental Health Conte Center Grant for the Neurobiology of Fear and Anxiety. Further studies in the McEwen lab seek to understand the cellular and molecular mechanisms for these changes, including the role of stress hormones.

The research, published in the June 28 issue of the Proceedings of the National Academy of Science, was supported by The Wellcome Trust.