Whether it's getting a cold during exam time or feeling run-down after a big meeting, we've all experienced feeling sick following a particularly stressful time at work or school. Is this merely coincidence, or is it possible that stress can actually make us sick? In a new report in Perspectives on Psychological Science, a journal of the Association for Psychological Science, psychologist Janice K. Kiecolt-Glaser from the Ohio State University College of Medicine reviews research investigating how stress can wreak havoc on our bodies and provides some suggestions to further our understanding of this connection.

The field of psychoneuroimmunology (PNI) investigates how stress and negative emotions (such as depression and anxiety) affect our health. Over the past 30 years, researchers in this field have uncovered a number of ways that stress adversely affects our health, and specifically, how stress can damage our immune system. Numerous studies have shown that stressed individuals show weaker immune responses to vaccines, and as Kiecolt-Glaser observes, "The evidence that stress and distress impair vaccine responses has obvious public health relevance because infectious diseases can be so deadly." Stress and depression have been shown to increase the risk of getting infections and also result in delayed wound healing.

Inflammation is the body's way of removing harmful stimuli and also starts the process of healing, via release of a variety of chemicals known as proinflammatory cytokines (e.g., interleukin-6). However, too much inflammation can be damaging and has been implicated in the development of many age-related diseases, including Alzheimer's Disease, Parkinson's disease, arthritis, and Type II diabetes. Negative emotions and psychological stressors increase the production of proinflammatory cytokines. A recent study revealed that men and women who serve as caregivers to spouses with dementia (and thus are under constant stress) have a four times larger annual rate of increase in serum interleukin-6 levels compared to individuals without caregiving responsibilities.

What's more, the changes in interleukin-6 levels among former caregivers did not differ from current caregivers, even following the death of the impaired spouse, indicating that chronic stress may cause the immune system to age quickly. Kiecolt-Glaser notes, "These stress-related changes in inflammation provide evidence of one mechanism through which stressors may accelerate risk of a host of age-related diseases."

Kiecolt-Glaser argues that our environment should be taken into account when studying the link between stress and our health. For instance, diet may modify interactions between psychological and immunological responses: Omega-3 fatty acids (found in fish and walnuts) can reduce production of some proinflammtory chemicals and increasing levels of omega-3 fatty acids may result in positive effects on mood and the immune system. Environmental toxins (such as pesticides and air pollutants) can have extremely negative effects on the immune system and these effects may be intensified in stressed individuals, increasing their risk for developing allergies, asthma, and viral infections.

Kiecolt-Glaser suggests that to most effectively tackle the questions raised by recent PNI research, cross-discipline training needs to be emphasized for students. Psychology students who gain a strong foundation in areas such as biology and physiology will be able to enter into powerful collaborations with scientists conducting immunology research. Kiecolt-Glaser concludes that the questions answered by these collaborations will advance PNI as well as psychology in general.

"By providing key data on how stressful events and the emotions they evoke get translated into health," she suggested, "psychology will assume a more dominant role in the health sciences, in health promotion, and in public health policy."

Women experiencing physical abuse from intimate partners spent 42 percent more on health care per year than non-abused women, according to a long-term study of more than 3,000 women. And the costs don't end when the abuse does. The study revealed that women who suffered physical abuse five or more years earlier still spent 19 percent more per year on health care than women who were never abused. "Along with all the physical and emotional pain it causes, domestic violence also comes with a substantial financial price," said Amy Bonomi, co-author of the study and associate professor of human development and family science at Ohio State University.

The study is the largest to date to examine health care costs and utilization based on the timing and type of domestic violence that women suffer, Bonomi said. The study, co-authored with researchers from the Group Health Cooperative and the University of Washington in Seattle, was published online this week in the journal Health Services Research. It will appear in an upcoming print edition.

The research examined data from 3,333 randomly selected women who belonged to Group Health, a health care system in the Pacific Northwest. Women in the study were surveyed about whether they experienced any physical or emotional abuse from intimate partners and if so, when it occurred. Researchers then studied patterns of health care use and costs by the women over an 11-year period, from 1992 through 2002.

"We were able to track health care costs for quite a long time, giving us a good picture of how much domestic violence is actually costing our health care system," Bonomi said. Women experiencing ongoing physical abuse had the highest health care costs -- 42 percent higher than non-abused women. "It's likely that these women need more health care because they are seeking care for immediate injuries and associated health problems," Bonomi said. Women who had been physically abused within the last five years, but not currently, had 24 percent higher yearly health costs. Abuse that occurred more than five years ago resulted in 19 percent higher costs.

The study separately examined women who experienced psychological abuse, which included verbal threats and chronic controlling behavior. Those suffering psychological abuse within the past five years, but not currently, had yearly health care costs that were 33 percent higher than those of non-abused women. "It's possible that it takes additional time for women with psychological abuse to seek care for their experiences," Bonomi said.

Another striking finding was that all abused women, whether they experienced physical or psychological abuse, used significantly more mental health services than non-abused women, Bonomi said. Women suffering ongoing physical abuse were about 2.5 times more likely to visit a mental health provider in the past year than were non-abused women. The rate for psychologically abused women was two times higher. "This lends support to the idea that mental health providers should always ask women about their abuse history when they first come in for treatment," Bonomi said.

But mental health was just one of several areas in which abused women used more services. Physically abused women used significantly more primary care, pharmacy, specialty care, laboratory and radiology services. For psychologically abused women, more services were needed in specialty care, pharmacy, and radiology.

Group Health, the health care system whose members were surveyed for the study, provides health and insurance services to more than 500,000 people in the Pacific Northwest.

Before flying off the handle the next time someone cuts you off in traffic, consider the latest research from Yale School of Medicine researchers that links changes brought on by anger or other strong emotions to future arrhythmias and sudden cardiac arrests, which are blamed for 400,000 deaths annually.

The study—led by Rachel Lampert, M.D., associate professor of medicine at Yale School of Medicine, and published in the Journal of the American College of Cardiology—deepens our understanding of how anger and other types of mental stress can trigger potentially lethal ventricular arrhythmias.

Lampert and her team studied 62 patients with implantable cardioverter-defibrillators (ICDs) and enlarged hearts. They were monitored three months after the ICD was implanted and then given a mental stress test requiring them to recall a stressful situation that angered them.

Lampert and her team sought to discover whether T-wave alternans (TWA), which monitor electrical instability in the heart induced by anger, would predict future ventricular arrhythmias. The team found that those in the group with more anger-induced electrical instability were more likely to experience arrhythmias one year after the study than those in the control group.

"Further studies are needed to determine whether there is a role for therapies which may reduce anger and the body's response to stress, thereby preventing arrhythmias in those at risk," said Lampert.

Lampert's work builds on past research linking strong emotion to sudden cardiac death. It has been found that devastating disasters, such as earthquakes, are linked to sudden death.

Creates harmful environment that may affect health, well-being

Amendments that restrict civil marriage rights of same-sex couples – such as Proposition 8 that recently passed in California – have led to higher levels of stress and anxiety among lesbian, gay, bisexual and transgender adults, as well as among their families of origin, according to several new studies to be published by the American Psychological Association.

One quantitative and two qualitative studies on the impact of anti-GLBT legislation appear in a special issue of the Journal of Counseling Psychology, published by APA. That issue of the journal, to be published in January, will be titled: "Advances in Research with Sexual Minority People."

The quantitative study was based on an online survey of 1,552 lesbian, gay and bisexual adults from all 50 states and the District of Columbia examining "minority stress," or the chronic social stress that minorities experience as a result of social stigmatization. Participants were grouped into those living in the seven states with an amendment on the ballot in November 2006 that did pass; those living in the 18 states with an amendment that passed before 2006; and those in the 23 states (plus D.C.) with no amendment. (Those living in Alabama, where an amendment passed in June 2006, were excluded because of the timing, as were those living in Arizona, where an amendment was defeated.)

The survey results documented increased minority stress, as well as more general psychological distress, among LGB individuals following the passage of a marriage amendment in 2006, compared to LGB people in states without an amendment on the 2006 ballot. The researchers, led by Sharon Scales Rostosky, Ph.D., at the University of Kentucky, found that those participants living in states that passed a measure in 2006 reported increased exposure to negative media messages and negative conversations. "The results of this study demonstrate that living in a state that has just passed a marriage amendment is associated with higher levels of psychological stress for lesbian, gay and bisexual citizens," Rostosky said. "And this stress is not due to other pre-existing conditions or factors; it is a direct result of the negative images and messages associated with the ballot campaign and the passage of the amendment."

The qualitative studies, while much smaller in scope, give voice to some of the people directly affected by anti-gay marriage amendments. The first study, "Balancing Dangers: GLBT Experience in a Time of Anti-GLBT Legislation," focused on 13 GLBT people living in Memphis, Tenn., who were interviewed at length about their experiences during the 2006 ballot campaign. The researchers, led by Heidi M. Levitt, Ph.D., at the University of Memphis, grouped the respondents' reactions into eight major themes, or "clusters." These included, for example: "Initiatives lead to constant painful reminders that I'm seen as less than human by our government and public laws," and "The irrationality of anti-GLBT initiatives and movements is baffling, painful and scary: We are not who they say we are."

Participants reported feeling not just alienated from their communities, but fearful that they would lose their children, that they would become victims of anti-gay violence or that they would need to move to a more accepting community. Some of these anxieties were mitigated by social support. For instance, one interviewee said he became "petrified …of being raped or roughed up or killed, you know, for doing nothing, basically. I worry about being picked out as a gay guy because my mannerisms are not entirely masculine." Another said the marriage amendment supporters were using the Bible "like a brick on us. They are beating us with it." Social support from religious institutions, families, GLBT friends and heterosexual allies led most of the participants "to greater feelings of safety, happiness and strength," the researchers wrote.

And in the third study, 10 family members of GLBT people living in Memphis were interviewed regarding how anti-GLBT initiatives and movements had affected their family. Their responses were also grouped into clusters of similar themes. "Some participants identified so deeply with their family member's experience that they felt equally attacked by these movements and policies," the researchers wrote. "They considered themselves members of the GLBT community and experienced rejection by others for being a GLBT family member."

"Typically, we tend to think of anti-GLBT policies such as marriage bans and Proposition 8 as affecting only GLBT people. However, our research suggests that others in addition to GLBT people are also impacted by this legislation and sometimes quite negatively. For example, we learned that some family members experienced a form of secondary minority stress. Although many participants displayed resiliency and effective coping with this stress, some experienced strong negative consequences to their mental and physical health," said Jennifer Arm, M.S.

Brent Mallinckrodt, Ph.D., editor of the Journal of Counseling Psychology, said the three articles provide empirical evidence of the harmful psychological and emotional effects of such measures. "This information is especially timely, as we see the emotionally charged reactions from GLBT people in the wake of the Proposition 8 passage in California," he said. "Psychologists serving GLBT clients and their families need to be aware of the real impact of these political forces on the everyday lives of the people most directly affected."

Lack of sleep, excessive computer screen time, stress and more hurt college students' GPAs

Lack of sleep, excessive television/computer screen time, stress, gambling, alcohol and tobacco use and other health-related issues are taking a toll on college students' academic performance, according to a study released by the University of Minnesota Boynton Health Service. "Our study shows that there is a direct link between college students' health and their academic achievement. This is the first time that anything like this has been published where Grade Point Average is linked to all these behaviors," said Dr. Ed Ehlinger, the director and chief health officer of the University of Minnesota Boynton Health Service. [view a video about the study]

Today's report, "Health and Academic Performance: Minnesota Undergraduate Students," is part of one of the most comprehensive studies of college students' health in the nation. About 24,000 students from 14 Minnesota colleges and universities were randomly selected to participate in this study and 9,931 completed the 2007 College Student Health Survey Report. The results only include undergraduate students from two-year and four-year institutions. All five University of Minnesota campuses were included in the survey.

In the results, 69.9 percent of college students reported they were stressed and 32.9 percent of those students said that stress was hurting their academic performance. In fact, the mean GPA for students saying stress impacted their academics was 3.12, compared with the 3.23 mean GPA for students who didn't believe it was affecting their academics. "While this may seem like a small difference in GPA, when you are looking at over 9,000 students the impact of this difference is huge," Ehlinger said. Twenty percent of students reported that sleep difficulties impacted their academics. In fact, those students who reported getting fewer nights of adequate sleep had a mean GPA of 3.08 compared with a 3.27 mean GPA for those who do not report sleep deficiencies. "The more days students get adequate sleep -- the better GPAs they attain," Ehlinger said. "There is a direct link between the two."

When it comes to excessive television and computer use (not including academic use), 30.4 percent of students surveyed reported excessive screen time. Thirteen percent of those with the issue reported that it impacted their studies; these students had a lower mean GPA of 3.04 compared with a mean GPA of 3.27 for those who said the problem did not impact them. "Turning off the computer or TV and going to sleep is one of the best things our students can do to improve their grades," Ehlinger said.

Students who reported that they had smoked during the past 30 days had a 3.12 mean GPA compared with a 3.28 mean GPA for students who reported not smoking. The study revealed surprising information for students who even smoke infrequently. "Even students who smoked once or twice in a month had lower GPAs than those who didn't smoke," Ehlinger said. "Using tobacco to calm down or 'to be social' is lowering students' grades."

Ehlinger hopes that this study's results will spur college students to change behavior and for colleges to pay more attention to the health of their students. "We hope this information helps students make wise decisions," Ehlinger said. "If you're investing a lot of time and money in your education, do you really want to waste your investment on behaviors that interfere with your academic success?"

The report also includes information on mental health, health insurance, physical activity levels, financial issues, drug use, injury, sexual assault and alcohol use. Members of the public, along with students and health officials, should pay attention to the results of this report, because the health of college students is important to society, Ehlinger said. "College students are so important for our economic development -- the development of our society," Ehlinger said. "One way to protect that investment in our future is to help them stay healthy."

Data from a new study suggests that individuals who engage in compassion meditation may benefit by reductions in inflammatory and behavioral responses to stress that have been linked to depression and a number of medical illnesses. The study's findings are published online at www.sciencedirect.com and in the medical journal Psychoneuroendocrinology.

"While much attention has been paid to meditation practices that emphasize calming the mind, improving focused attention or developing mindfulness, less is known about meditation practices designed to specifically foster compassion," says Geshe Lobsang Tenzin Negi, PhD, who designed and taught the meditation program used in the study. Negi is senior lecturer in the Department of Religion, the co-director of Emory Collaborative for Contemplative Studies and president and spiritual director of Drepung Loseling Monastery, Inc.

This study focused on the effect of compassion meditation on inflammatory, neuroendocrine and behavioral responses to psychosocial stress, and evaluated the degree to which engagement in meditation practice influenced stress reactivity. "Our findings suggest that meditation practices designed to foster compassion may impact physiological pathways that are modulated by stress and are relevant to disease," explains Charles L. Raison, MD, clinical director of the Mind-Body Program, Emory University's Department of Psychiatry and Behavioral Sciences, Emory School of Medicine, and a lead author on the study.

Sixty-one healthy college students between the ages of 17 and19 participated in the study. Half the participants were randomized to receive six weeks of compassion meditation training and half were randomized to a health discussion control group. Although secular in presentation, the compassion meditation program was based on a thousand-year-old Tibetan Buddhist mind-training practice called "lojong" in Tibetan. Lojong practices utilize a cognitive, analytic approach to challenge an individual's unexamined thoughts and emotions toward other people, with the long-term goal of developing altruistic emotions and behavior towards all people. Each meditation class session combined teaching, discussion and meditation practice.

The control group attended classes designed by study investigators on topics relevant to the mental and physical health of college students such as stress management, drug abuse and eating disorders. In addition, a variety of student participation activities were employed such as mock debates and role-playing. Both groups were required to participate in 12 hours of classes across the study period. Meditators were provided with a meditation compact disc for practice at home. Homework for the control group was a weekly self-improvement paper.

After the study interventions were finished, the students participated in a laboratory stress test designed to investigate how the body's inflammatory and neuroendocrine systems respond to psychosocial stress. No differences were seen between students randomized to compassion meditation and the control group, but within the meditation group there was a strong relationship between the time spent practicing meditation and reductions in inflammation and emotional distress in response to the stressor. Consistent with this, when the meditation group was divided into high and low practice groups, participants in the high practice group showed reductions in inflammation and distress in response to the stressor when compared to the low practice group and the control group.

"It will require conducting stress tests before and after meditation training in order to conclusively show it was the practice of compassion meditation that resulted in reduced stress responses," says study co-author Thaddeus W.W. Pace, PhD, assistant professor, Department of Psychiatry and Behavioral Sciences at Emory. "But these initial results are quite exciting," says Pace. "If practicing compassion meditation does reduce inflammatory responses to stress it might offer real promise as a means of preventing many conditions associated with stress and with inflammation including major depression, heart disease and diabetes." Raison concurs. "Based on the promising findings from this study we are planning to offer compassion meditation classes to patients at Emory Winship Cancer Institute, and have partnered with the Emory Predictive Health Institute to study potential long term effects of compassion meditation on health and well-being," says Raison.

A link between reduced levels of the 'stress hormone' cortisol and antisocial behaviour in male adolescents has been discovered by a research team at the University of Cambridge.

Levels of cortisol in the body usually increase when people undergo a stressful experience, such as public speaking, sitting an exam, or having surgery. It enhances memory formation and is thought to make people behave more cautiously and to help them regulate their emotions, particularly their temper and violent impulses.

The new research, funded by the Wellcome Trust, shows that adolescents with severe antisocial behaviour do not exhibit the same increase in cortisol levels when under stress as those without antisocial behaviour. These findings suggest that antisocial behaviour, at least in some cases, may be seen as a form of mental illness that is linked to physiological symptoms (involving a chemical imbalance of cortisol in the brain and body).

The scientists, led by Dr Graeme Fairchild and Professor Ian Goodyer, recruited participants for the study from schools, pupil referral units, and the Youth Offending Service. Samples of saliva were collected over several days from the subjects in a non-stressful environment to measure levels of the hormone under resting conditions. The young men then took part in a stressful experiment that was designed to induce frustration. Samples of saliva were taken immediately before, during and after the experiment to track how cortisol changed during stress.

The differences between participants with severe antisocial behaviour and those without were most marked under stressful conditions. While the average adolescents showed large increases in the amount of cortisol during the frustrating situation, cortisol levels actually went down in those with severe antisocial behaviour.

These results suggest that antisocial behaviour may be more biologically-based than previously considered, just as some individuals are more vulnerable to depression or anxiety due to their biological make-up. Dr Fairchild said, "If we can figure out precisely what underlies the inability to show a normal stress response, we may be able to design new treatments for severe behaviour problems. We may also be able create targeted interventions for those at higher risk. "A possible treatment for this disorder offers the chance to improve the lives of both the adolescents who are afflicted and the communities in which they live."

Workplace bullying, such as belittling comments, persistent criticism of work and withholding resources, appears to inflict more harm on employees than sexual harassment, say researchers who presented their findings at a conference today. “As sexual harassment becomes less acceptable in society, organizations may be more attuned to helping victims, who may therefore find it easier to cope,” said lead author M. Sandy Hershcovis, PhD, of the University of Manitoba. “In contrast, non-violent forms of workplace aggression such as incivility and bullying are not illegal, leaving victims to fend for themselves.” This finding was presented at the Seventh International Conference on Work, Stress and Health, co-sponsored by the American Psychological Association, the National Institute of Occupational Safety and Health and the Society for Occupational Health Psychology.

Hershcovis and co-author Julian Barling, PhD, of Queen’s University in Ontario, Canada, reviewed 110 studies conducted over 21 years that compared the consequences of employees’ experience of sexual harassment and workplace aggression. Specifically, the authors looked at the effect on job, co-worker and supervisor satisfaction, workers’ stress, anger and anxiety levels as well as workers’ mental and physical health. Job turnover and emotional ties to the job were also compared. The authors distinguished among different forms of workplace aggression. Incivility included rudeness and discourteous verbal and non-verbal behaviors. Bullying included persistently criticizing employees’ work; yelling; repeatedly reminding employees of mistakes; spreading gossip or lies; ignoring or excluding workers; and insulting employees’ habits, attitudes or private life. Interpersonal conflict included behaviors that involved hostility, verbal aggression and angry exchanges.

Both bullying and sexual harassment can create negative work environments and unhealthy consequences for employees, but the researchers found that workplace aggression has more severe consequences. Employees who experienced bullying, incivility or interpersonal conflict were more likely to quit their jobs, have lower well-being, be less satisfied with their jobs and have less satisfying relations with their bosses than employees who were sexually harassed, the researchers found. Furthermore, bullied employees reported more job stress, less job commitment and higher levels of anger and anxiety. No differences were found between employees experiencing either type of mistreatment on how satisfied they were with their co-workers or with their work. “Bullying is often more subtle, and may include behaviors that do not appear obvious to others,” said Hershcovis. “For instance, how does an employee report to their boss that they have been excluded from lunch? Or that they are being ignored by a coworker? The insidious nature of these behaviors makes them difficult to deal with and sanction.”

From a total of 128 samples that were used, 46 included subjects who experienced sexual harassment, 86 experienced workplace aggression and six experienced both. Sample sizes ranged from 1,491 to 53,470 people. Participants ranged from 18 to 65 years old. The work aggression samples included both men and women. The sexual harassment samples examined primarily women because, Hershcovis said, past research has shown that men interpret and respond differently to the behaviors that women perceive as sexual harassment.

Exercise has a similar effect to antidepressants on depression. This has been shown by previous research. Now Astrid Bjørnebekk at Karolinska Institutet has explained how this can happen: exercise stimulates the production of new brain cells.

In a series of scientific reports, she has searched for the underlying biological mechanisms that explain why exercise can be a form of therapy for depression and has also compared it with pharmacological treatment with an SSRI drug.

The experiment studies were conducted on rats. The results show that both exercise and antidepressants increase the formation of new cells in an area of the brain that is important to memory and learning. Astrid Bjørnebekk's studies confirm previous research results, and she proposes a model to explain how exercise can have an antidepressant effect in mild to moderately severe depression. Her study also shows that exercise is a very good complement to medicines.

"What is interesting is that the effect of antidepressant therapy can be greatly strengthened by external environmental factors," she says.

Previous studies have shown that drug abusers have lowered levels of the dopamine D2 receptor in the brain's reward system. It has been speculated that this may be of significance to the depressive symptoms drug abusers often suffer from. These rat studies show that genetic factors may influence how external environmental factors can regulate levels of the dopamine D2 receptor in the brain.

"Different individuals may have differing sensitivity to how stress lowers dopamine D2 receptor levels, for example. This might be significant in explaining why certain individuals develop depression more readily than others," she says.

Smoking reduction may lead to unexpected quitting
In a review article in the December Nicotine and Tobacco Research, researchers at the University of Vermont have found an unexpected, effective alternative to motivate smokers to quit smoking – cutting back. According to the qualitative review of 19 studies on smoking reduction in individuals who did not want to quit, this method, typically coupled with the use of nicotine replacement products, led to an increase in quitting in 16 of the studies.

"Cutting back is approved as a method of quitting in several European countries, but not in the United States," said lead author John Hughes, M.D., a professor of psychiatry at the University of Vermont College of Medicine. "Our review contradicts the commonly held belief that quitting requires stopping abruptly and provides evidence that smokers can quit successfully by reducing the amount of cigarettes smoked. Furthermore, our review indicates cutting back is often a great way to start changing smoking that can lead to eventual quitting."

Hughes's report is the largest review of smoking reduction studies published to date. Among the 19 studies reviewed (many of which were randomized, placebo-controlled trials), the two considered the most important involved randomized, controlled trials that assigned smokers to either reduce or not reduce. Both of these studies found that smoking reduction leads to more cessation. Also, in three studies, the effect of reduction was found to be similar to the effect of providing smoking cessation advice. Based on this finding, Hughes suggests that clinicians try recommending reduction for smokers who have not responded to repeated cessation advice.

Hughes and colleague Matthew Carpenter warn that smokers do need to understand that there is no good evidence that cutting back alone decreases smoking-related health risks and thus clinicians should promote reduction only as a step towards eventual cessation to their patients.

Few U.S. troops returning from Iraq and Afghanistan are being directed to treatment for post-traumatic stress disorder (PTSD), according to a Government Accountability Office report that was to be released Thursday.

The report found that only about one in five members of the U.S. military who, through a screening program, were found to be at risk for PTSD were referred by government doctors for further help, the Washington Post reported.

Defense Department officials couldn't explain why so few troops were referred for treatment, the report said.

Some veterans groups have charged that the U.S. government is playing down the risk of PTSD because it's concerned about the cost of dealing with it, the Post reported.

Of 9,145 service personnel at risk for PTSD, 22 percent were referred for help. The Army and Air Force each referred 23 percent of personnel at risk, compared with 18 percent for the Navy, and about 15 percent for the Marines, the report found.

HealthScout -- 12 May 2006
Copyright © 2006 ScoutNews LLC.

Researchers from the University of Cincinnati have found that eating or drinking sweets may decrease the production of the stress-related hormone glucocorticoid—which has been linked to obesity and decreased immune response.

“Glucocorticoids are produced when psychological or physical stressors activate a part of the brain called the ‘stress axis,’” said Yvonne Ulrich-Lai, PhD, a postdoctoral fellow in the department of psychiatry. “These hormones help an individual survive and recover from stress, but have been linked to increased abdominal obesity and decreased immune function when produced in large amounts.

“Finding another way to affect the body’s response to stress and limit glucocorticoid production could alleviate some of these dangerous health effects.”

The laboratory findings were presented during a poster session Tuesday, Nov. 15, at the annual Society for Neuroscience meeting in Washington, D.C.

Dr. Ulrich-Lai and a team of researchers from the department of psychiatry showed that when laboratory rats chose to eat or drink sweet snacks their bodies produced lower levels of glucocorticoid.

She said that sweets—especially those made from sugar, not artificial sweetener—might do the trick.

"The sweets we are talking about are not the low-calorie, sugar-substitute variety,” said Dr. Ulrich-Lai. “We actually found that sugar snacks, not artificially sweetened snacks, are better ‘self-medications’ for the two most common types of stress—psychological and physical.”

Psychological stress could involve things such as public speaking, being threatened, or coping with the death of a loved one. Examples of physical stress are injury, illness, or prolonged exposure to cold.

During the study, researchers gave adult male rats free access to food and water and also offered them a small amount of sugar drink, artificially sweetened drink, or water twice a day. After two weeks, the rats were given a physical and psychological stress challenge. Following both types of stress, rats that had consumed the sugar drink had lower glucocorticoid levels than those that drank the water. Those drinking the artificially sweetened drink showed only slightly reduced glucocorticoid levels.

Dr. Ulrich-Lai noted that although her team was not studying the health effects of the sweetened drinks, they did not notice a body-weight increase in the rats consuming the sugar drinks.

James Herman, PhD, co-author, professor and stress neurobiologist in the department of psychiatry, said the next step will be to determine how these sweetened drinks are decreasing glucocorticoid production.

“We need to find out if there are certain parts of the brain that control the response to stress, then determine if the function of these brain regions are changed by sugar snacking,” he said.

Co-authors also included Dennis Choi and Michelle Ostrander, PhD, both of UC’s psychiatry department.

University of Cincinnati Medical Center News
15 November 2005

Commuting is never fun, and is almost always stressful, in part because we often have no control over what happens to us. But everyday we get in our car, or board the train or bus, and make our way to work, having become accustomed to this stress, not realizing that this stress may have a measurable affect on our brain.

Although we do not yet know if this is the case for humans, new research in rats from the laboratory of Rockefeller University’s Bruce McEwen, Ph.D., shows that chronic, uncontrollable stress of repeated confinement leads to gradual changes in brain structure over weeks. Yet, even a single acute stress of putting a rat in a tube where it cannot move freely also causes a structural change in the brain, not immediately but over days, along with higher levels of anxiety. These results may help scientists understand what is happening in the human brain during post-traumatic stress disorder and other anxiety disorders and depressive illness.

In earlier studies, McEwen and colleagues had looked at changes in the hippocampus and the prefrontal cortex, areas of the brain that respond to repeated, confinement stress and which are important in memory storage and retrieval. Turning to a different area of the brain called the amygdala, which is thought to play a role in fear and anxiety memories, they wanted to see if it too was involved in processing stressful experiences. Indeed they found that repeated stress increased anxiety as well as a form of aggression.

“Understanding how the whole nervous system functions, how the different areas of the brain interact, is vital to understanding the neurological basis of depressive illness and anxiety disorders,” says McEwen, who is the Alfred E. Mirsky Professor and head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at Rockefeller. “And we knew of some evidence that the neurons in the amygdala are more active in depression and anxiety disorders.”

“The new paper, conducted in collaboration with Dr. Sumantra Chattarji’s laboratory in Bangalore, India, and MIT, shows that even a single stressful event in these animals can have a measurable and delayed influence on the architecture of their brains, and on their behavior,” adds McEwen. “We would like to think that these findings might become relevant in understanding conditions like post-traumatic stress disorder and depression.”

The follow-up of this paper is under investigation in collaborative studies with investigators at the Weill Medical College of Cornell University, Mt. Sinai School of Medicine and New York University under a National Institute of Mental Health Conte Center Grant for the Neurobiology of Fear and Anxiety. Further studies in the McEwen lab seek to understand the cellular and molecular mechanisms for these changes, including the role of stress hormones.

The research, published in the June 28 issue of the Proceedings of the National Academy of Science, was supported by The Wellcome Trust.