Do you know someone who claims to remember their first day of kindergarten? Or a trip they took as a toddler? While some people may be able to recall trivial details from the past, laboratory research shows that the human memory can be remarkably fragile and even inventive. In fact, people can easily create false memories of their past and a new study shows that such memories can have long-term effects on our behavior.

Psychologists Elke Geraerts of the University of St. Andrews and Maastricht University, Daniel Bernstein of Kwantlen Polytechnic University and the University of Washington, Harald Merckelbach, Christel Linders, and Linsey Raymaekers of Maastricht University, and Elizabeth F. Loftus of University of California, Irvine, found that it is possible to change long-term behaviors using a simple suggestive technique.

In a series of experiments, the researchers falsely suggested that participants had become ill after eating egg salad as a child. Afterwards, the researchers offered different kinds of sandwiches to the participants, including ones with an egg salad filling. Four months later, the participants were asked to be in a separate study in which they evaluated egg salad as well as other foods. They were then given the same kinds of sandwiches that had been offered to them four months earlier.

Interestingly, participants who were told they had become ill as a child after eating egg salad showed a distinct change in attitudes and behavior towards this food after the experiment. They not only gave the food lower evaluations than participants who did not develop false memories or were in the control group, but they also avoided egg salad sandwiches more than any of the other participants four months later.

The results, appearing in the August issue of Psychological Science, a journal of the Association for Psychological Science, "clearly demonstrate that false suggestions about childhood events can profoundly change people's attitudes and behavior," wrote the authors.

These findings have significant implications for the authenticity of reports of recovered memory experiences. While previous research indicates that spontaneously recovered memories may reflect real memories of abuse, there is no such evidence for abuse memories recovered through suggestive therapy. The results might also influence obesity treatments and dieting choices. The authors suggest that it may be possible for people to learn to avoid certain foods by believing they had negative experiences with the food as a child. Overall, this study clearly demonstrates that false suggestions about childhood events can profoundly change people's attitudes and behavior.

A period of slumber helps the brain distinguish core emotions from background details

As poets, songwriters and authors have described, our memories range from misty water-colored recollections to vividly detailed images of the times of our lives. Now, a study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Boston College offers new insights into the specific components of emotional memories, suggesting that sleep plays a key role in determining what we remember – and what we forget.

Reported in the August 2008 issue of the journal Psychological Science, the findings show that a period of slumber helps the brain to selectively preserve and enhance those aspects of a memory that are of greatest emotional resonance, while at the same time diminishing the memory's neutral background details. "This tells us that sleep's role in emotional memory preservation is more than just mechanistic," says the study's first author Jessica Payne, PhD, a Harvard University research fellow in the Division of Psychiatry at BIDMC. "In order to preserve what it deems most important, the brain makes a tradeoff, strengthening the memory's emotional core and obscuring its neutral background."

Previous studies have established the key role that sleep plays in procedural memory, demonstrating that the consolidation of procedural skills (such as typing or playing the piano) is greatly enhanced following a period of sleep. But sleep's importance in the development of episodic memories – in particular, those with emotional resonance– has been less clear.

"Emotional memories usually contain highly charged elements – for example, the car that sideswiped us on the ride home – along with other elements that are only tangentially related to the emotion, such as the name of the street we were traveling on or what store we'd just passed," explains study author Elizabeth Kensinger, PhD, an Assistant Professor in the College of Arts and Sciences at Boston College. "We were interested in examining whether sleep would affect memory for all of these elements equally, or whether sleep might allow some of the event features to decay at a faster rate than others."

The authors tested 88 college students. Study participants were shown scenes that depicted either neutral subjects on a neutral background (a car parked on a street in front of shops) or negatively arousing subjects on a neutral background (a badly crashed car parked on a similar street). The participants were then tested separately on their memories of both the central objects in the pictures and the backgrounds in the scenes. In this way, memory could be compared for the emotional aspects of a scene (the crashed car) versus the non-emotional aspects of the scene (the street on which the car had crashed.)

Subjects were divided into three groups. The first group underwent memory testing after 12 hours spent awake during the daytime; the second group was tested after 12 nighttime hours, including their normal period of nighttime sleep; and the third baseline group was tested 30 minutes after viewing the images, in either the morning or evening.

"Our results revealed that the study subjects who stayed awake all day largely forgot the entire negative scene [they had seen], with their memories of both the central objects and the backgrounds decaying at similar rates," says Payne. But, she adds, among the individuals who were tested after a period of sleep, memory recall for the central negative objects (i.e. the smashed car) was preserved in detail.

"After an evening of sleep, the subjects remembered the emotional items [smashed car] as accurately as the subjects whose memories had been tested only 30 minutes after looking at the scenes," explains Kensinger. "By contrast, sleep did little to preserve memory for the backgrounds [i.e. street scenes] and so memory for those elements reached a comparably low level after a night of sleep as it did after a day spent awake."

"This is consistent with the possibility that the individual components of emotional memory become 'unbound' during sleep," adds Payne, explaining that "unbinding" enables the sleeping brain to selectively preserve only that information which it calculates to be most salient and worthy of remembering. A real-world example of this tradeoff, she adds, is the "weapon focus effect" in which crime victims vividly remember an assailant's weapon, but have little memory for other important aspects of the crime scene. Traumatic memories, such as the flashbacks experienced among individuals with post-traumatic stress disorder, can demonstrate similar disparities, with some aspects of an experience seemingly engraved in memory while other details are erased.

"Sleep is a smart, sophisticated process," adds Payne. "You might say that sleep is actually working at night to decide what memories to hold on to and what to let go of."

A shove, a taunt or name-calling on the playground or in the hall, away from the eyesight, earshot and authority of the teacher – childhood bullying can involve physical contact, spreading rumors and other negative behaviors committed over and over again to intimidate, humiliate and isolate the receiver of the behavior. A review of national and international research on the issue is finding a family connection to the origins of young bullies. Elizabeth Sweeney, a University of Cincinnati master's degree student in sociology, presented her findings Aug. 3 at the 103rd annual meeting of the American Sociological Association.

Sweeney reviewed research out of England, Germany, Norway, Japan, South Africa and the United States, which she reports lagged behind the European countries in examining the phenomenon of bullying prior to this decade. The majority of the research that she examined involved children between the ages of nine and 16. Sweeney says her review of the literature found that children raised by authoritarian parents – parents who are demanding, directive and unresponsive – are the most prone to act out bullying behavior. On the other hand, there were parallels showing that children raised by nurturing, warm, responsive parents were less likely to bully.

"Children who experience hostility, abuse, physical discipline and other aggressive behaviors by their parents are more likely to model that behavior in their peer relationships," she writes. "Children learn from their parents how to behave and interact with others," Sweeney says. "So if they're learning about aggression and angry words at home, they will tend to use these behaviors as coping mechanisms when they interact with their peers." Her review also found that children from middle-income families were less likely to bully than children from the high and low ends of the family income scale.

She says that while some studies suggest boys are more prone to bullying than girls, others state that it runs equally among the genders, although boys are more likely to act out bullying physically, while girls are more verbal. Sweeney adds that it is the tolerance of bullying that "has served as one of the primary contributors to its persistence and severity." She is advocating research that would delve more deeply into the issues of bullying, including in-depth interviews with children, families and school officials.

Study questions the effectiveness of the current movie-rating system

In a paper published in the August issue of the journal Pediatrics, Dartmouth researchers document the alarming numbers of young adolescents age 10-14 who are exposed to graphic violence in movies rated R for violence. They found that these extremely violent movies were seen by an average of 12.5 percent of an estimated 22 million children age 10-14. One R-rated movie, Scary Movie, was seen by an estimated 10 million children, or about 48 percent of 10-14 year olds.

"Our data reveal a disturbingly high rate of exposure among 10-14 year olds nationally to extremely violent movies," says Keilah Worth, the lead author on the study and a post-doctoral fellow at Dartmouth Medical School and at Dartmouth-Hitchcock Medical Center's Norris Cotton Cancer Center. "In Britain, no adolescent would be admitted to these movies unless they were 18. The R rating in this country is clearly not preventing our young people from seeing them."

Many scientific studies have established the connection between exposure to media violence and aggression and violence in children. For example, playing video games can lead to changes in attitudes and behavior as well as desensitization to actual violence. "We know so much about the harmful effects of exposure to violent media content, but how much exposure children actually get has been largely ignored. Now, we're learning more about the large numbers of kids seeing this material and who they are," says Worth.

For this assessment of exposure to violence in movies, the researchers used data from national telephone surveys of more than 6,500 adolescents age 10-14 in 2003. Out of 532 recent releases, the researchers chose to look at exposure to 40 of the most violent movies. The study also revealed some independent risk factors for exposure: boys, minorities, those with lower socioeconomic status, and those with lower academic performance were all more likely to see extremely violent movies. Black male adolescents were at particularly high risk of seeing these movies. For example, Blade, Training Day, and Scary Movie were seen by 37 percent, 27 percent, and 48 percent respectively of all the adolescents surveyed, compared to 82 percent, 81 percent, and 81 percent of black males.

"No expert in child development would advocate for subjecting children as young as 10 to this level of violence, yet the study shows that such exposure is commonplace in this country," says James Sargent, the senior scientist on this study and a professor of pediatrics at Dartmouth Medical School. "We should re-think the current movie rating system, which has been in place for 40 years, and was designed when kids could only see movies in theaters. Ratings need to be more prominent on all movies, whether they are seen in theaters or purchased in the store, and we need clearer messages to parents. Pediatricians and child advocates should instruct parents to strictly abide by the movie-age guidelines and to closely monitor movie viewing."

Findings help identify mechanism of age-related memory deficits, highlight the importance of sleep for memory

Aging impairs the consolidation of memories during sleep, a process important in converting new memories into long-term ones, according to new animal research in the July 30 issue of The Journal of Neuroscience. The findings shed light on normal memory mechanisms and how they are disrupted by aging.

During sleep, the hippocampus, a brain region important in learning and memory, repeatedly "replays" brain activity from recent awake experiences. This replay process is believed to be important for memory consolidation. In the new study, Carol Barnes, PhD, and colleagues at the University of Arizona found reduced replay activity during sleep in old compared to young rats, and rats with the least replay activity performed the worst in tests of spatial memory.

Barnes and colleagues recorded hippocampal activity in 11 young and 11 old rats as they navigated several mazes for food rewards. Later, when the animals were asleep, the researchers recorded their hippocampal activity again. In the young animals, the sequence of neural activity recorded while the animals navigated the mazes was repeated when they slept. However, in most of the old animals, the sequence of neural activity recorded during sleep did not reflect the sequence of brain activity recorded in the maze. "These findings suggest that some of the memory impairment experienced during aging could involve a reduction in the automatic process of experience replay," said Michael Hasselmo, DPhil, at Boston University, an expert unaffiliated with the study.

Animals with more faithful sleep replay also performed better on memory tests. The researchers tested the same 22 rats on a spatial learning and memory task. Consistent with previous research, the young rats recalled the solution to the spatial task faster and more accurately than the old rats. In the old group, the researchers found that the top performers in the spatial memory task were also the ones that showed the best sleep replay. Irrespective of the animal's age, the researchers found that animals who more faithfully replayed the sequence of neural activity recorded in the maze while asleep also performed better on the spatial memory task. "This is the first study to suggest that an animal's ability to perform a spatial memory task may be related to the brain's ability to perform memory consolidation during sleep," said study author Barnes.

Identification of the specific memory deficit present in the aging brain may be a first step to preventing age-related memory loss. "This study's findings could inspire the development and testing of pharmacological agents designed to enhance memory replay phenomena," Hasselmo said.

Despite the fact that pediatricians recommend no screen media exposure for children under age 2, three-quarters of very young children in America live in homes where the television is on most of the time, according to research. A new study has found that leaving your TV set on disrupts young children while they are playing, even if the channel is tuned to adult shows. This means that simply having the TV on, even in the background, may be detrimental to children's development. The study, conducted by researchers at the University of Massachusetts, is published in the July/August 2008 issue of the journal Child Development.

The researchers looked at 50 children ages 1, 2, and 3. Each child came to a lab with a parent and was invited to play for an hour with a variety of age-appropriate toys. For half the time, a television was on in the room, showing an episode of the adult game show Jeopardy!, with commercials; during the other half hour, the TV was turned off.

Researchers observed the children as they played to determine whether background TV—defined as adult-oriented television that is on and may be watched by older members of the family, but which very young children don't understand and to which they pay little attention—affected the children's behavior during play.

Background TV was found to disrupt the toy play of the children at every age, even when they paid little attention to it. When the television was on, the children played for significantly shorter periods of time and the time they spent focused on their play was shorter, compared to when the TV was off.

"Background TV, as an ever-changing audiovisual distractor, disrupts children's efforts to sustain attention to ongoing play behaviors," according to Marie Evans Schmidt, who is now a research associate at the Center on Media and Child Health at Children's Hospital Boston and is the lead author of the study. "Background TV is potentially a chronic environmental risk factor affecting most American children. Parents should limit their young children's exposure to background television."

Gait recognition software could improve security surveillanceat a distance

Biometrics is commonly associated retinal scans, iris recognition and DNA databases, but researchers in India are working on another form of biometrics that could allow law enforcement agencies and airport security to recognize suspects based on the way they were, their characteristic gait. The team reveals details of a comprehensive framework for gait recognition by computer in the inaugural issue of the Inderscience publication, the International Journal of Biometrics.

C. Nandini of the Vidya Vikas Institute of Engineering & Technology and C.N. Ravi Kumar of the S.J. College of Engineering in Mysore, India, explain that human gait typifies the motion characteristics of an individual. Viewed from the side, we each have a unique gait that makes us easily recognizable. They point out that a camera with a side view can record a set of key frames, or stances, as a person heads for the security desk at an airport, military installation or bank, for instance. Key frames over the person's complete walk cycle, can then be converted into silhouette form and statistical analysis using so-called Shannon entropy, together with height measurements and the periodicity of the gait usedto classify the person's gait. The gait of individuals checking in at an airport could then be compared with the database, perhaps even before they enter the airport concourse. Such data compared with CCTV footage might also be used to track suspect terrorists or criminals who may otherwise be disguising their features or be carrying forged documents.

The researchers emphasize that gait recognition has a significant advantage over more well-known biometrics, such as fingerprinting and iris scanning in that it is entirely unobtrusive and can be used to identify an individual potentially from a considerable distance. "The ability to identify a possible threat from a distance gives personnel a longer time frame in which to react before a possible suspect becomes a real threat," the researchers say.

They carried out initial tests on 20 people recorded walk in a straight line at normal speed and stride, back and forth in front of a video camera placed perpendicular to their path. They obtained good recognition rates using the Shannon entropy equation and the individuals' height. Recognition performance of the system was sensitive to changes in big viewing angle above ten degrees but was reasonably robust even when the individuals changed walking speed.

Insufficient sleep among adolescents may not only contribute to lower grades and a lack of motivation, but may also increase the odds of serious levels of emotional and behavioral disturbances. The study, authored by Fred Danner, PhD, of the University of Kentucky, focused on 882 high school freshmen who provided informationabout their sleep habits and school grades and also completed psychological and behavioral assessments.

According to the results, students reported sleeping, on average, 7.6 hours per school night, with 48 percent reporting less than eight hours. Hours of sleep per school night were significantly positively associated with GPA and level of motivation, and significantly negatively associated with clinically significant levels of emotional disturbance and ADHD. Each additional hour of sleep on school nights lowered the odds of scoring in the clinically significant range of emotional disturbance and ADHD by 25 percent and 34 percent, respectively.

“Since these findings are based on associations rather than direct experimental manipulation, they cannot conclusively prove that insufficient sleep causes a loss of motivation, poor grades,ADHD, and emotional disturbance during adolescence,” said Dr. Danner. “The results, however, are consistent with a growing body of research that many adolescents do not get sufficient sleep and that even mild chronic sleep deprivation has serious effects on their psychological functioning. Lack of sleep should no longer be considered a traditional adolescent rite of passage because it can have serious consequences.”

It is recommended that adolescents get nine hours of nightly sleep. The American Academy of Sleep Medicine (AASM) offers the following tips on how to get a good night’s sleep:

• Follow a consistent bedtime routine.
• Establish a relaxing setting at bedtime.
• Get a full night’s sleep every night.
• Avoid foods or drinks that contain caffeine, as well as any medicine that has a stimulant, prior to bedtime.
• Do not stay up all hours of the night to “cram” for an exam, do homework, etc. If after-school activities are proving to be too time-consuming, consider cutting back on these activities.
• Keep computers and TVs out of the bedroom.
• Do not go to bed hungry, but don’t eat a big meal before bedtime either.
• Avoid any rigorous exercise within six hours of your bedtime.
• Make your bedroom quiet, dark and a little bit cool.
• Get up at the same time every morning.

Those who suspect that they might be suffering from a sleep disorder are encouraged to consult with their primary care physicianor a sleep specialist.

Women and men tend to have different types of stress-related psychological disorders. Women have greater rates of depression and some types of anxiety disorders than men, while men have greater rates of alcohol-use disorders than women. A new study of emotional and alcohol-craving responses to stress has found that when men become upset, they are more likely than women to want alcohol.

Results will be published in the July issue of Alcoholism: Clinical & Experimental Research.

“We know that women and men respond to stress differently,” said Tara M. Chaplin, associate research scientist at Yale University School of Medicine and first author of the study. “For example, following a stressful experience, women are more likely than men to say that they feel sad or anxious, which may lead to risk for depression and anxiety disorders. Some studies have found that men are more likely to drink alcohol following stress than women. If this becomes a pattern, it could lead to alcohol-use disorders.”

As part of a larger study, the researchers exposed 54 healthy adult social drinkers (27 women, 27 men) to three types of imagery scripts – stressful, alcohol-related, and neutral/relaxing – in separate sessions, on separate days and in random order. Chaplin and her colleagues then assessed participants’ subjective emotions, behavioral/bodily responses, cardiovascular arousal as indicated by heart rate and blood pressure, and self-reported alcohol craving.

“After listening to the stressful story, women reported more sadness and anxiety than men,” said Chaplin, “as well as greater behavioral arousal. But, for the men … emotional arousal was linked to increases in alcohol craving. In other words, when men are upset, they are more likely to want alcohol.”

These findings – in addition to the fact that the men drank more than the women on average – meant that the men had more experience with alcohol, perhaps leading them to turn to alcohol as a way of coping with distress, added Chaplin. “Men’s tendency to crave alcohol when upset may be a learned behavior or may be related to known gender differences in reward pathways in the brain,” she said. “And this tendency may contribute to risk for alcohol-use disorders.”

There is a greater societal acceptance of “emotionality,” particularly sadness and anxiety, in women than in men, noted Chaplin.

“Women are more likely than men to focus on negative emotional aspects of stressful circumstances, for example, they tend to ‘ruminate’ or think over and over again about their negative emotional state,” she said. “Men, in contrast, are more likely to distract themselves from negative emotions, to try not to think about these emotions. Our finding that men had greater blood pressure response to stress, but did not report greater sadness and anxiety, may reflect that they are more likely to try to distract themselves from their physiological arousal, possibly through the use of alcohol.”

If you are struggling to retrieve a word that you are certain is on the tip of your tongue, or trying to perfect a slapshot that will send your puck flying into a hockey net, or if you keep stumbling over the same sequence of notes on the piano, be warned: you might be unconsciously creating a pattern of failure, a new study reveals.

The research appeared on April 1 in The Quarterly Journal of Experimental Psychology.

Karin Humphreys, assistant professor in McMaster University’s Faculty of Science, and Amy Beth Warriner, an undergraduate student in the Department of Psychology, Neuroscience & Behaviour, suggest that most errors are repeated because the very act of making a mistake, despite receiving correction, constitutes the learning of that mistake.

Humphreys says the research came about as a result of her own experiences of repeatedly getting into a tip-of-the-tongue (or TOT) state on particular words. “This can be incredibly frustrating – you know you know the word, but you just can’t quite get it,” she said. “And once you have it, it is such a relief that you can’t imagine ever forgetting it again. But then you do. So we began thinking about the mechanisms that might underlie this phenomenon. We realized that it might not be a case of everyone having certain words that are difficult for them to remember, but that by getting into a tip-of-the-tongue state on a particular word once, they actually learn to go into that incorrect state when they try to retrieve the same word again.”

Humphreys and Warriner tested 30 students to see if their subjects could retrieve words after being given a definition. e.g. “What do you call an instrument for performing calculations by sliding beads along rods or grooves” (Answer: abacus). They then had to say whether they knew the answer, didn’t know it, or were in a TOT. If they were in a TOT, they were randomly assigned to spend either 10 or 30 seconds trying to retrieve the answer before finally being shown it. Two days later, subjects were tested on those same words again. One would assume that having been shown the correct word on Day 1 the subject would still remember it on Day 2. Not so. The subjects tended to TOT on the same words as before, and were especially more likely to do so if they had spent a longer time trying to retrieve them The longer time in the error state appears to reinforce that incorrect pattern of brain activation that caused the error.

“It’s akin to spinning one’s tires in the snow: despite your perseverance you’re only digging yourself a deeper rut,” the researchers explained. There might be a strategy to solve the recurrence of tip-of-the-tongue situations, which is what Warriner is currently working on for her honors thesis. "If you can find out what the word is as soon as possible—by looking it up, or asking someone—you should actually say it to yourself,” says Humphreys. “It doesn't need to be out loud, but you should at least say it to yourself. By laying down another procedural memory you can help ameliorate the effects of the error. However, what the research shows is that if you just can't figure it out, stop trying: you’re just digging yourself in deeper."

Can we train ourselves to be compassionate? A new study suggests the answer is yes. Cultivating compassion and kindness through meditation affects brain regions that can make a person more empathetic to other peoples' mental states, say researchers at the University of Wisconsin-Madison. Published March 26 in the Public Library of Science One, the study was the first to use functional magnetic resonance imaging (fMRI) to indicate that positive emotions such as loving-kindness and compassion can be learned in the same way as playing a musical instrument or being proficient in a sport. The scans revealed that brain circuits used to detect emotions and feelings were dramatically changed in subjects who had extensive experience practicing compassion meditation.

The research suggests that individuals - from children who may engage in bullying to people prone to recurring depression - and society in general could benefit from such meditative practices, says study director Richard Davidson, professor of psychiatry and psychology at UW-Madison and an expert on imaging the effects of meditation. Davidson and UW-Madison associate scientist Antoine Lutz were co-principal investigators on the project. The study was part of the researchers' ongoing investigations with a group of Tibetan monks and lay practitioners who have practiced meditation for a minimum of 10,000 hours. In this case, Lutz and Davidson worked with 16 monks who have cultivated compassion meditation practices. Sixteen age-matched controls with no previous training were taught the fundamentals of compassion meditation two weeks before the brain scanning took place.

Many contemplative traditions speak of loving-kindness as the wish for happiness for others and of compassion as the wish to relieve others' suffering. Loving-kindness and compassion are central to the Dalai Lama's philosophy and mission," says Davidson, who has worked extensively with the Tibetan Buddhist leader. "We wanted to see how this voluntary generation of compassion affects the brain systems involved in empathy."

Various techniques are used in compassion meditation, and the training can take years of practice. The controls in this study were asked first to concentrate on loved ones, wishing them well-being and freedom from suffering. After some training, they then were asked to generate such feelings toward all beings without thinking specifically about anyone. Each of the 32 subjects was placed in the fMRI scanner at the UW-Madison Waisman Center for Brain Imaging, which Davidson directs, and was asked to either begin compassion meditation or refrain from it. During each state, subjects were exposed to negative and positive human vocalizations designed to evoke empathic responses as well as neutral vocalizations: sounds of a distressed woman, a baby laughing and background restaurant noise.

"We used audio instead of visual challenges so that meditators could keep their eyes slightly open but not focused on any visual stimulus, as is typical of this practice," explains Lutz. The scans revealed significant activity in the insula - a region near the frontal portion of the brain that plays a key role in bodily representations of emotion - when the long-term meditators were generating compassion and were exposed to emotional vocalizations. The strength of insula activation was also associated with the intensity of the meditation as assessed by the participants. "The insula is extremely important in detecting emotions in general and specifically in mapping bodily responses to emotion - such as heart rate and blood pressure - and making that information available to other parts of the brain," says Davidson, also co-director of the HealthEmotions Research Institute.

Activity also increased in the temporal parietal juncture, particularly the right hemisphere. Studies have implicated this area as important in processing empathy, especially in perceiving the mental and emotional state of others. "Both of these areas have been linked to emotion sharing and empathy," Davidson says. "The combination of these two effects, which was much more noticeable in the expert meditators as opposed to the novices, was very powerful."

The findings support Davidson and Lutz's working assumption that through training, people can develop skills that promote happiness and compassion. "People are not just stuck at their respective set points," he says. "We can take advantage of our brain's plasticity and train it to enhance these qualities." The capacity to cultivate compassion, which involves regulating thoughts and emotions, may also be useful for preventing depression in people who are susceptible to it, Lutz adds. "Thinking about other people's suffering and not just your own helps to put everything in perspective," he says, adding that learning compassion for oneself is a critical first step in compassion meditation.

The researchers are interested in teaching compassion meditation to youngsters, particularly as they approach adolescence, as a way to prevent bullying, aggression and violence. "I think this can be one of the tools we use to teach emotional regulation to kids who are at an age where they're vulnerable to going seriously off track," Davidson says. Compassion meditation can be beneficial in promoting more harmonious relationships of all kinds, Davidson adds. "The world certainly could use a little more kindness and compassion," he says. "Starting at a local level, the consequences of changing in this way can be directly experienced."

Lutz and Davidson hope to conduct additional studies to evaluate brain changes that may occur in individuals who cultivate positive emotions through the practice of loving-kindness and compassion over time.

Stories about the “terrible twos” abound in parenting lore. New research published in the March/April 2008 issue of the journal Child Development finds that the way mothers and their 2-year-olds relate to each other affects the quality but not the frequency of conflicts when children are two, and that children’s temperament also plays a role.

Researchers at Lehigh University and the University of California-Davis recruited 60 mothers and their children through birth announcements in local newspapers, then observed them in two sessions: one 50-minute lab visit when the children were 30 months old, and one 90-minute home visit when the children were 36 months. During each observation, the researchers looked at all episodes of conflict, and examined whether they contained compromise, justification, or aggravation (i.e., simple insistence without explanation or threats) by both mothers and children. They also examined whether the conflicts were resolved. Mothers provided information about the children’s temperament and attachment security, or the degree of trust that children have in their mothers’ responsiveness and availability.

The study found that mother-child conflict during both observations was frequent (about 20 times an hour), and there was a lot of variation in the frequency of conflict (from as many as 55 times an hour to as few as 5 times an hour) and in the quality of conflict between mothers and children.

Furthermore, children’s temperament was related to the frequency and quality of conflict, that is, children who were highly active and who had problems controlling their behavior had more conflict with mothers than less active children and children who did not have trouble controlling their behavior. In addition, highly active children and children who frequently and intensely experienced negative emotions had less constructive conflict with their mothers, involving less resolution, more aggravation, and less justification, than children who did not have these qualities.

Attachment security was not related to the frequency of conflict between mothers and their children, but to the quality, the study found. Mothers and children who had secure relationships had constructive conflict involving high levels of resolution, compromise, and justification. In sum, both the quality of children’s relationships with their mothers and children’s personality types were found to shape the nature of conflict between mothers and their children at age two.

“Children with difficult temperaments tend to have more frequent and less constructive conflict with mothers,” according to Deborah Laible, associate professor of psychology at Lehigh University and the lead author of the study. “High-quality relationships between mothers and children were associated with more constructive conflict between mothers and children. In secure relationships, both mothers and children seem committed to maintaining relational harmony by resolving conflict, compromising, and justifying their side of an argument.”

Students who bully others tend to have difficulties with other relationships, such as those with friends and parents. Targeting those relationships, as well as the problems children who bully have with aggression and morality, may offer ideas for intervention and prevention. Those are the findings of a new study that was conducted by scientists at York University and Queens University. It appears in the March/April 2008 issue of the journal Child Development.

The researchers looked at 871 students (466 girls and 405 boys) for seven years from ages 10 to 18. Each year, they asked the children questions about their involvement in bullying or victimizing behavior, their relationships, and other positive and negative behaviors.

Bullying is a behavior that most children engage in at some point during their school years, according to the study. Almost a tenth (9.9 percent) of the students said they engaged in consistently high levels of bullying from elementary through high school. Some 13.4 percent said they bullied at relatively high levels in elementary school but dropped to almost no bullying by the end of high school. Some 35.1 percent of the children said they bullied peers at moderate levels. And 41.6 percent almost never reported bullying across the adolescent years.

The study also found that children who bullied tended to be aggressive and lacking in a moral compass and they experienced a lot of conflict in their relationships with their parents. In addition, their relationships with friends also were marked by a lot of conflict, and they tended to associate with others who bullied. The findings provide clear direction for prevention of persistent bullying problems, according to Debra Pepler, Distinguished Research Professor of Psychology at York University and Senior Associate Scientist at the Hospital for Sick Children. Pepler, who is the study’s lead author, calls bullying “a relationship problem.”

“Interventions must focus on the children who bully, with attention to their aggressive behavior problems, social skills, and social problem-solving skills. A focus on the child alone is not sufficient. Bullying is a relationship problem that requires relationship solutions by focusing on the bullying children’s strained relationships with parents and risky relationships with peers,” according to Pepler. “By providing intensive and ongoing support starting in the elementary school years to this small group of youth who persistently bully, it may be possible to promote healthy relationships and prevent their ‘career path’ of bullying that leads to numerous social-emotional and relationship problems in adolescence and adulthood.”

Rofé, Yacov (2008). Does repression exist? Memory, pathogenic, unconscious and clinical evidence. Review of General Psychology, 12 (1), 63-85.

Abstract: The current dispute regarding the existence of repression has mainly focused on whether people remember or forget trauma. Repression, however, is a multidimensional construct, which, in addition to the memory aspect, consists of pathogenic effects on adjustment and the unconscious. Accordingly, in order to arrive at a more accurate decision regarding the existence of repression, studies relevant to all three areas are reviewed. Moreover, since psychoanalysis regards repression as a key factor in accounting for the development and treatment of neurotic disorders, relevant research from these two domains are also taken into account. This comprehensive evaluation reveals little empirical justification for maintaining the psychoanalytic concept of repression. (emphasis added)

Hundreds of thousands of Australians count snakes and spiders among their fears, and while scientists have previously assumed we possess an evolutionary predisposition to fear the unpopular animals, researchers at UQ's School of Psychology look to have proved otherwise. According to Dr Helena Purkis, the results of the UQ study could provide an unprecedented insight into just why the creepy creatures are so widely feared.

“Previous research shows we react differently to snakes and spiders than to other stimuli, such as flowers or mushrooms, or even other dangerous animals….or cars and guns, which are also much more dangerous,” Dr Purkis said. “[In the past, this] has been explained by saying that people are predisposed by evolution to fear certain things, such as snakes and spiders, that would have been dangerous to our ancestors. [However], people tend to be exposed to a lot of negative information regarding snakes and spiders, and we argue this makes them more likely to be associated with phobia.”

In the study, researchers compared the responses to stimuli of participants with no particular experience with snakes and spiders, to that of snake and spider experts.

“Previous research has argued that snakes and spiders attract preferential attention (they capture attention very quickly) and that during this early processing a negative (fear) response is generated… as an implicit and indexed subconscious [action],” Dr Purkis said. “We showed that although everyone preferentially attends to snakes or spiders in the environment as they are potentially dangerous, only inexperienced participants display a negative response.”

The study is the first to establish a clear difference between preferential attention and the accompanying emotional response: that is, that you can preferentially attend to something without a negative emotional response being elicited. Dr Purkis said the findings could significantly increase understanding about the basic cognitive and emotional processes involved in the acquisition and maintenance of fear.

“If we understand the relationship between preferential attention and emotion it will help us understand how a stimulus goes from being perceived as potentially dangerous, to eliciting an emotional response and to being associated with phobia,” she said. “[This] could give us some information about the way people need to deal with snakes and spiders in order to minimise negative emotional responses.”

UQ News Online

Scientists have revealed what may well be the first pervasive ‘rule’ of evolution. In a study published in the Proceedings of the National Academy of Sciences researchers have found evidence which suggests that evolution drives animals to become increasingly more complex.

Looking back through the last 550 million years of the fossil catalog to the present day, the team investigated the different evolutionary branches of the crustacean family tree. They were seeking examples along the tree where animals evolved that were simpler than their ancestors. Instead they found organisms with increasingly more complex structures and features, suggesting that there is some mechanism driving change in this direction.

“If you start with the simplest possible animal body, then there’s only one direction to evolve in – you have to become more complex,” said Dr Matthew Wills from the Department of Biology & Biochemistry at the University of Bath who worked with colleagues Sarah Adamowicz from the University of Waterloo (Canada) and Andy Purvis from Imperial College London.

“Sooner or later, however, you reach a level of complexity where it’s possible to go backwards and become simpler again. What’s astonishing is that hardly any crustaceans have taken this backwards route. Instead, almost all branches have evolved in the same direction, becoming more complex in parallel. This is the nearest thing to a pervasive evolutionary rule that’s been found. Of course, there are exceptions within the crustacean family tree, but most of these are parasites, or animals living in remote habitats such as isolated marine caves. For those free-living animals in the ‘rat-race’ of evolution, it seems that competition may be the driving force behind the trend. What’s new about our results is that they show us how this increase in complexity has occurred. Strikingly, it looks far more like a disciplined march than a milling crowd.”

Dr Adamowicz said: “Previous researchers noticed increasing morphological complexity in the fossil record, but this pattern can occur due to the chance origination of a few new types of animals. Our study uses information about the inter-relatedness of different animal groups – the ‘Tree of Life’ – to demonstrate that complexity has evolved numerous times independently.”

Like all arthropods, crustaceans’ bodies are built up of repeating segments. In the simplest crustaceans, the segments are quite similar - one after the other. In the most complex, such as shrimps and lobsters, almost every segment is different, bearing antennae, jaws, claws, walking legs, paddles and gills.

The American biologist Leigh Van Valen coined the phrase ‘Red Queen’ for the evolutionary arms race phenomenon. In Through the Looking-Glass Lewis Carroll’s Red Queen advises Alice that: “It takes all the running you can do, to keep in the same place.”

“Those crustacean groups going extinct tended to be less complex than the others around at the time,” said Dr Wills. “There’s even a link between average complexity within a group and the number of species alive today. “All organisms have a common ancestor, so that every living species is part of a giant family tree of life.”

Dr Adamowicz added: “With a few exceptions, once branches of the tree have separated they continue to evolve independently. Looking at many independent branches is similar to viewing multiple repeated runs of the tape of evolution. Our results apply to a group of animals with bodies made of repeated units. We must not forget that bacteria – very simple organisms – are among the most successful living things. Therefore, the trend towards complexity is compelling but does not describe the history of all life.”

Neuroanatomist Jill Bolte Taylor had an opportunity few brain scientists would wish for: One morning, she realized she was having a massive stroke. As it happened -- as she felt her brain functions slip away one by one, speech, movement, understanding -- she studied and remembered every moment. This is a powerful story about how our brains define us and connect us to the world and to one another.

Jill Bolte Taylor: My Stroke of Insight

Counterproductive Cameras At Traffic Lights
Researchers in Florida contend that cameras for catching drivers who run red lights actually increase accidents and injuries.

60-Second Science from Scientific American podcasts
12 March 2008

Workplace bullying, such as belittling comments, persistent criticism of work and withholding resources, appears to inflict more harm on employees than sexual harassment, say researchers who presented their findings at a conference today. “As sexual harassment becomes less acceptable in society, organizations may be more attuned to helping victims, who may therefore find it easier to cope,” said lead author M. Sandy Hershcovis, PhD, of the University of Manitoba. “In contrast, non-violent forms of workplace aggression such as incivility and bullying are not illegal, leaving victims to fend for themselves.” This finding was presented at the Seventh International Conference on Work, Stress and Health, co-sponsored by the American Psychological Association, the National Institute of Occupational Safety and Health and the Society for Occupational Health Psychology.

Hershcovis and co-author Julian Barling, PhD, of Queen’s University in Ontario, Canada, reviewed 110 studies conducted over 21 years that compared the consequences of employees’ experience of sexual harassment and workplace aggression. Specifically, the authors looked at the effect on job, co-worker and supervisor satisfaction, workers’ stress, anger and anxiety levels as well as workers’ mental and physical health. Job turnover and emotional ties to the job were also compared. The authors distinguished among different forms of workplace aggression. Incivility included rudeness and discourteous verbal and non-verbal behaviors. Bullying included persistently criticizing employees’ work; yelling; repeatedly reminding employees of mistakes; spreading gossip or lies; ignoring or excluding workers; and insulting employees’ habits, attitudes or private life. Interpersonal conflict included behaviors that involved hostility, verbal aggression and angry exchanges.

Both bullying and sexual harassment can create negative work environments and unhealthy consequences for employees, but the researchers found that workplace aggression has more severe consequences. Employees who experienced bullying, incivility or interpersonal conflict were more likely to quit their jobs, have lower well-being, be less satisfied with their jobs and have less satisfying relations with their bosses than employees who were sexually harassed, the researchers found. Furthermore, bullied employees reported more job stress, less job commitment and higher levels of anger and anxiety. No differences were found between employees experiencing either type of mistreatment on how satisfied they were with their co-workers or with their work. “Bullying is often more subtle, and may include behaviors that do not appear obvious to others,” said Hershcovis. “For instance, how does an employee report to their boss that they have been excluded from lunch? Or that they are being ignored by a coworker? The insidious nature of these behaviors makes them difficult to deal with and sanction.”

From a total of 128 samples that were used, 46 included subjects who experienced sexual harassment, 86 experienced workplace aggression and six experienced both. Sample sizes ranged from 1,491 to 53,470 people. Participants ranged from 18 to 65 years old. The work aggression samples included both men and women. The sexual harassment samples examined primarily women because, Hershcovis said, past research has shown that men interpret and respond differently to the behaviors that women perceive as sexual harassment.

A team of researchers from Canada and Japan have uncovered some remarkable results on how eastern and western cultures assess situations very differently. Across two studies, participants viewed images, each of which consisted of one centre model and four background models in each image. The researchers manipulated the facial emotion (happy, angry, sad) in the centre or background models and asked the participants to determine the dominant emotion of the centre figure.

The majority of Japanese participants (72%) reported that their judgments of the centre person’s emotions were influenced by the emotions of the background figures, while most North Americans (also 72%) reported they were not influenced by the background figures at all. “What we found is quite interesting,” says Takahiko Masuda, a Psychology professor from the University of Alberta. “Our results demonstrate that when North Americans are trying to figure out how a person is feeling, they selectively focus on that particular person’s facial expression, whereas Japanese consider the emotions of the other people in the situation.” This may be because Japanese attention is not concentrated on the individual, but includes everyone in the group, says Masuda.

For the second part of the study, researchers monitored the eye movements of the participants and again the results indicated that the Japanese looked at the surrounding people more than the westerners when judging the situation. While both the Japanese and westerners looked to the central figure during the first second of viewing the photo, the Japanese looked to the background figures at the very next second, while westerners continued to focus on the central figure.

"East Asians seem to have a more holistic pattern of attention, perceiving people in terms of the relationships to others," says Masuda. "People raised in the North American tradition often find it easy to isolate a person from its surroundings, while East Asians are accustom to read the air "kuuki wo yomu" of the situation through their cultural practices, and as a result, they think that even surrounding people's facial expressions are an informative source to understand the particular person's emotion.”

The theory that depression is caused by a chemical imbalance is often presented in the media as fact even though there is little scientific evidence to support it, according to a new study co-authored by a Florida State University visiting lecturer. Jeffrey Lacasse, an FSU doctoral candidate and visiting lecturer in the College of Social Work, and Jonathan Leo, a neuroanatomy professor at Lincoln Memorial University in Tennessee, found that reporters who included statements in news articles about depression being caused by a chemical imbalance, or a lack of serotonin in the brain, were unable to provide scientific evidence to support those statements.

Lacasse and Leo spent about a year in late 2006 and 2007 monitoring the daily news for articles that included statements about chemical imbalances and contacting the authors to request evidence that supported their statements. Several reporters, psychiatrists and a drug company responded to the researchers' requests, but Lacasse and Leo said they did not provide documentation that supported the chemical imbalance theory. Their findings were published in the journal Society.

"The media's presentation of the theory as fact is troublesome because it misrepresents the current status of the theory," Lacasse said. "For instance, there are few scientists who will rise to its defense, and some prominent psychiatrists publicly acknowledge that the serotonin hypothesis is more metaphor than fact. As the current study documents, when asked for evidence, reporters were unable to cite peer-reviewed primary articles in support of the theory." Moreover, the researchers said, several of the responses received from reporters seem to suggest a fundamental misunderstanding of the theory's scientific status. The "Diagnostic and Statistical Manual of Mental Disorders," which almost all psychiatrists use to diagnose and treat their patients, clearly states that the cause of depression and anxiety is unknown, according to Lacasse and Leo.

The Society article builds on the pair's 2005 study, which focused on pharmaceutical advertisements that claim depression is caused by an imbalance of serotonin—an imbalance the drug companies say can be corrected by a class of antidepressants called Selective Serotonin Reuptake Inhibitors (SSRIs). "The chemical imbalance theory, which was formulated in the 1960s, was based on the observation that mood could be artificially altered with drugs, rather than direct observation of any chemical imbalances," Leo said. "Since then there has been no direct evidence to confirm the theory and a significant number of findings cast doubt on the theory."

The researchers said the popularity of the theory is in large part based on the presumed efficacy of the SSRIs, but they say that several large studies now cast doubt on this efficacy. A review of a full set of trial data published in the journal PLoS (Public Library of Science) Medicine last month concluded that much of the perceived efficacy of several of the most common SSRIs was due to the placebo effect. Other studies indicate that for every 10 people who take an SSRI, only one to two people are truly receiving benefit from the medication, according to Lacasse and Leo.

Still, the National Center for Health Statistics found that antidepressants are the most prescribed drugs in the United States, with doctors writing more than 31 million prescriptions in 2005. Both Lacasse and Leo emphasized the importance of patients being given factual information so they can make informed decisions about medications and the role of other potentially useful interventions, such as psychotherapy, exercise or self-help strategies. "Patients might make different choices about the use of medications and possibly use alternative approaches to their distress if they were fully informed," Lacasse said. "We believe the media can play a positive role by ensuring that their mental health reporting is congruent with scientific literature."

FSU News
March 2008

Cochlear implant recipients experience a significant improvement in their quality of life, and have improved speech recognition, according to new research published in the March 2008 issue of Otolaryngology – Head and Neck Surgery.

The German study evaluated the quality of life of 56 cochlear implant recipients using the Nijmegen Cochlear Implant Questionnaire (NCIQ), a self-administered assessment that asks responders about sound perception, speech, self-esteem, and social interaction. Responders reported significant improvements in all areas, with especially large gains observed in the areas of sound perception and social interaction. The study also gauged participants using the Medical Outcome Study Short Form 36 (SF36). While the results provided by this tool are not specific to hearing loss or cochlear implants, they nonetheless indicated significant improvements in the areas of social functioning and mental health.

A cochlear implant is an electronic device that restores partial hearing to the deaf. It is surgically implanted in the inner ear and activated by a device worn outside the ear. Unlike a hearing aid, it does not make sound louder or clearer. Instead, the device bypasses damaged parts of the auditory system and directly stimulates the hearing nerve, allowing individuals who are profoundly hearing-impaired to receive sound.

Brain imaging reveals drivers are distracted even if they don't talk

Carnegie Mellon University scientists have shown that just listening to a cell phone while driving is a significant distraction, and it causes drivers to commit some of the same types of driving errors that can occur under the influence of alcohol. The use of cell phones, including dialing and texting, has long been a safety concern for drivers. But the Carnegie Mellon study, for the first time, used brain imaging to document that listening alone reduces by 37 percent the amount of brain activity associated with driving. This can cause drivers to weave out of their lane, based on the performance of subjects using a driving simulator.

The findings, to be reported in an upcoming issue of the journal Brain Research, show that making cell phones hands-free or voice-activated is not sufficient in eliminating distractions to drivers. “Drivers need to keep not only their hands on the wheel; they also have to keep their brains on the road,” said neuroscientist Marcel Just, director of the Center for Cognitive Brain Imaging. Other distractions, such as eating, listening to the radio or talking with a passenger, also can divert a driver. Though it is not known how these activities compare to cell phone use, Just said there are reasons to believe cell phones may be especially distracting. “Talking on a cell phone has a special social demand, such that not attending to the cell conversation can be interpreted as rude, insulting behavior,” he noted. A passenger, by contrast, is likely to recognize increased demands on the driver’s attention and stop talking.

The 29 study volunteers used a driving simulator while inside an MRI brain scanner. They steered a car along a virtual winding road at a fixed, challenging speed, either while they were undisturbed, or while they were deciding whether a sentence they heard was true or false. Just’s team used state-of-the-art functional magnetic resonance imaging (fMRI) methods to measure activity in 20,000 brain locations, each about the size of a peppercorn. Measurements were made every second.

The driving-while-listening condition produced a 37 percent decrease in activity of the brain’s parietal lobe, which is associated with driving. This portion of the brain integrates sensory information and is critical for spatial sense and navigation. Activity was also reduced in the occipital lobe, which processes visual information. The other impact of driving-while-listening was a significant deterioration in the quality of driving. Subjects who were listening committed more lane maintenance errors, such as hitting a simulated guardrail, and deviating from the middle of the lane. Both kinds of influences decrease the brain’s capacity to drive well, and that decrease can be costly when the margin for error is small.

“The clear implication is that engaging in a demanding conversation could jeopardize judgment and reaction time if an atypical or unusual driving situation arose,” Just said. “Heavy traffic is no place for an involved personal or business discussion, let alone texting.” Because driving and listening draw on two different brain networks, scientists had previously suspected that the networks could work independently on each task. But Just said this study demonstrates that there is only so much that the brain can do at one time, no matter how different the two tasks are.

The study emerges from the new field of neuroergonomics, which combines brain science with human-computer interaction studies that measure how well a technology matches human capabilities. Neuroergonomics is beginning to be applied to the operation of vehicles like aircraft, ships and cars in which drivers now have navigation systems, iPods and even DVD players at their disposal. Every additional input to a driver consumes some of his or her brain capacity, taking away some of the resources that monitor for other vehicles, lane markers, obstacles, and sudden changes in conditions.

“Drivers’ seats in many vehicles are becoming highly instrumented cockpits,” Just said, “and during difficult driving situations, they require the undivided attention of the driver’s brain.”

Creative Play Makes for Kids in Control
In a preschool in Bridgeton, New Jersey, children are learning to develop important cognitive and self-regulation skills -- through play.

NPR Morning Edition (28 Feb 2008)
by Alix Spiegel

Some of the oldest tales and wisest mythology allude to the snake as a mischievous seducer, dangerous foe or powerful iconoclast; however, the legend surrounding this proverbial predator may not be based solely on fantasy. As scientists from the University of Virginia recently discovered, the common fear of snakes is most likely intrinsic.

Evolutionarily speaking, early humans who were capable of surviving the dangers of an uncivilized society adapted accordingly. And the same can be said of the common fear of certain animals, such as spiders and snakes: The ancestors of modern humans were either abnormally lucky or extraordinarily capable of detecting and deterring the threat of, for example, a poisonous snake.

Psychologists Vanessa LoBue and Judy DeLoache were able to show this phenomenon by examining the ability of adults and children to pinpoint snakes among other nonthreatening objects in pictures. “We wanted to know whether preschool children, who have much less experience with natural threats than adults, would detect the presence of snakes as quickly as their parents,” LoBue explained. “If there is an evolved tendency in humans for the rapid detection of snakes, it should appear in young children as well as their elders.”

Preschool children and their parents were shown nine color photographs on a computer screen and were asked to find either the single snake among eight flowers, frogs or caterpillars, or the single nonthreatening item among eight snakes. As the study surprisingly shows, parents and their children identified snakes more rapidly than they detected the other stimuli, despite the gap in age and experience.

The results, which appear in the March 2008 issue of Psychological Science, a journal of the Association for Psychological Science, may provide the first evidence of an adapted, visually-stimulated fear mechanism in humans.

Primer describes current understanding of human taste perception and biology

Despite the significance of taste to both human gratification and survival, a basic understanding of this primal sense is still unfolding. Taste provides both pleasure and protection. Often taken for granted, the sense of taste evaluates everything humans put into their mouths. Taste mediates recognition of a substance and the final decision process before it is either swallowed and taken into the body, or rejected as inappropriate.

A new primer written by scientists at the Monell Center and Florida State University and published in the February 26 issue of Current Biology, provides a clear and accessible overview of recent advances in understanding human taste perception and its underlying biology.

Within the past few years, identification of receptors for sweet, bitter and umami (savory) taste has led to new insights regarding how taste functions, but many questions remain to be answered. The Current Biology primer reviews the current state of knowledge regarding how taste stimuli are detected and ultimately translated by the nervous system into the perceptual experiences of sweet, sour, salty, bitter, and umami.

Such perceptual evaluations are related to the function and ultimately, the consequences, of taste evaluation. These can range from pleasurable emotional reactions, for example the delight a child receives from a sweet candy, to the critical life-dependent response that causes a person to spit out a bitter potential toxin.

Author Paul A.S. Breslin, PhD, a sensory scientist at the Monell Center, observes, “For all mammals, the collective influence of taste over a lifetime has a huge impact on pleasure, health, well being, and disease. Taste’s importance to our daily lives is self-evident in its metaphors – for example: the ‘sweetness’ of welcoming a newborn child, the ‘bitterness’ of defeat, the ‘souring’ of a relationship, and describing a truly good human as the ‘salt’ of the earth.”

25 February 2008

Eric Chudler at Neuroscience for Kids has recently added Neuroscience on Stamps.

Scientific American -- Science Talk
(6 February 2008)

In this episode, University of California, Berkeley, linguist Alice Gaby talks about the relationships among language, culture, cognition and perception.

Queensland Brain Institute (QBI) scientists have found another important clue to why nerve cells die in neurodegenerative diseases, based on studies of the developing brain. Neuroscientists at The University of Queensland have just published findings, which add more weight to the "use it or lose it" model for brain function.

QBI's Dr Elizabeth Coulson said a baby's brain generates roughly double the number of nerve cells it needs to function; with those cells that receive both chemical and electrical stimuli surviving, and the remaining cells dying. In research published in the "Journal of Neuroscience", Dr Coulson and her colleagues have identified a crucial step in the cell-death process. "It appears that if a cell is not appropriately stimulated by other cells, it self-destructs," Dr Coulson said.

This self-destruct process is also known to be an important factor in stroke, Alzheimer's and motor neuron diseases, leading to the loss of essential nerve cells from the adult brain. "We know that a lack of both chemical and electrical stimuli causes the cells to self-destruct," Dr Coulson said. "But we believe that nerve cells will survive if appropriate electrical stimuli are produced to block the self-destruct process that we have identified." The researchers' next step is to test whether dying cells receiving only electrical stimulation can be rescued.

More than three years' research has gone into understanding these crucial factors regulating nerve cell survival, but it is a major step in the long process of discovery needed to combat neurodegeneration. QBI Director, Professor Perry Bartlett said the research is an extremely exciting finding because it also provides the missing piece of information as to how the brain likely keeps alive the new neurons it generates in some brain areas as an adult. "Combining this with our knowledge of how to stimulate new neurons in the brain of adults following to disease processes such as stroke, it provides new mechanisms for the treatment of a variety of diseases from depression to dementia," he said.

Very young brains process memories of fear differently than more mature ones, new research indicates. The findings appear in the Feb. 6 issue of The Journal of Neuroscience. The work significantly advances scientific understanding of when and how fear is stored and unlearned, and introduces new thinking on the implications of fear experience early in life.

“This important paper raises questions that are the ‘tip of the iceberg’ related to the very complex series of events that occur as we learn to fear something. In the real world, we become fearful, extinguish that fear, reacquire it at another time, and then conquer it yet again,” says John Krystal, MD, of Yale University and director of the clinical neuroscience division of the VA National Center for Post-Traumatic Stress Disorder. “Typically, we think about long-term, negative impact of fear learning, such as lifelong problems with anxiety. But this work highlights an avenue for adapting to early stresses that apparently can occur only early in life: to erase a learned fear from memory.” Krystal was not affiliated with the research.

Study co-authors Jee Hyun Kim and Rick Richardson, PhD, of the University of New South Wales in Sydney, homed in on the amygdala, using anesthesia to temporarily inactivate it and therefore isolate its role. The amygdala is critical for emotional learning and plays a central role in dulling the memory of a fear. Kim and Richardson trained rats that were 16 and 23 days old—the human equivalent of children and budding adolescents—to associate a specific sound with a mild shock to the foot. After subsequent training, when the sound was not followed by a shock, the animals’ fearful reaction to hearing the sound faded. Technically, this is known as “extinction,” and depended on the function of the amygdala.

In a second round of training, the researchers reintroduced the fear and tried to re-extinguish it. This time around, they found, only the older rats were able to do so without the amygdala. The researchers concluded that the age at which the initial extinction training occurred was critical to whether or not the rats’ fear faded the second time independently of the amygdala. The authors suggest that in the very young, it is primarily the amygdala that extinguishes fearful memories, but that mechanisms independent of the amygdala develop later.

This raises the possibility that fears unlearned at an early enough age are, in fact, erased. As brains develop, however, and related structures near the amygdala mature, these structures take on a greater role. Thus, fear in adolescence and later in life may not be erased, but instead be, for example, inhibited by a process of overlaying neutral memories on top of the initial fear reaction. The initial memory could still exist and be called on again. “Extinction in the young brain might forever erase early traumatic learning—but accepting this hypothesis will have to wait for more research,” says Mark Bouton, PhD, of the University of Vermont, who did not participate in the esearch. “What might change as the brain develops is where and how fear learning and extinction are stored and how they can be retrieved.”

In the first study to use imaging technology to see what goes on in the brain when we scratch, researchers at Wake Forest University Baptist Medical Center have uncovered new clues about why scratching may be so relieving – and why it can be hard to stop. The work is reported online in the Journal of Investigative Dermatology and will appear in a future print issue.

"Our study shows for the first time how scratching may relieve itch,” said lead author Gil Yosipovitch, M.D., a dermatologist who specializes in itch. “It’s important to understand the mechanism of relief so we can develop more effective treatments. For some people, itch is a chronic condition that affects overall health.” The study involved 13 healthy participants who underwent testing with functional magnetic resonance imaging (MRI) technology that highlights areas of the brain activated during an activity. Participants were scratched on the lower leg with a small brush. The scratching went on for 30 seconds and was then stopped for 30 seconds – for a total of about five minutes.

“To our surprise, we found that areas of the brain associated with unpleasant or aversive emotions and memories became significantly less active during the scratching,” said Yosipovitch. “We know scratching is pleasurable, but we haven’t known why. It’s possible that scratching may suppress the emotional components of itch and bring about its relief.” The reduced brain activity occurred in the anterior cingulate cortex, an area associated with aversion to unpleasant sensory experiences, and the posterior cingulate cortex, which is associated with memory. When participants reported that the scratching felt most intense, activation in these areas was lowest.

Yosipovitch said patients occasionally report that intense scratching – to the point of drawing blood – is the only thing that relieves chronic itch. “This is the first real scientific evidence showing that itch may be inhibited by scratching,” he said. “Of course, scratching is not recommended because it can damage the skin. But understanding how the process works could lead to new treatments. For example, drugs that deactivate this part of the brain might be effective.”

The imaging studies also showed that some areas of the brain were made more active by the scratching, including the secondary somatosensory cortex, a sensory area involved in pain, and the prefrontal cortex, which is associated with compulsive behavior. “This could explain the compulsion to continue scratching,” said Yosipovitch.

One drawback to the study is that the scratching occurred in the absence of itch. Yosipovitch’s team is continuing the research by evaluating whether the findings will apply to chronic itch. Understanding more about chronic itch is important, Yosipovitch said, noting that more than 30 million Americans suffer from eczema and that almost half (42 percent) of kidney dialysis patients are bothered by moderate to severe itch. In fact, those kidney dialysis patients with itch have a 17 percent higher mortality rate, likely from a loss of sleep, according to a report in Nephrology Dialysis Transplantation.


Wake Forest University Baptist Medical Center News
31 January 2008

Another crack at non-addictive opioids? Why we don't get hooked on our own endorphins.
by Maia Szalavitz at 60-Second Science
29 January 2008

Four days’ exposure to a REM sleep deprivation procedure reduces cell proliferation in the part of the forebrain that contributes to long-term memory of rats, according to a study published in the February 1 issue of the journal SLEEP. [abstract] The study, authored by Dennis McGinty, PhD, of the V.A. Greater Los Angeles Healthcare System, focused on male Sprague-Dawley rats.

REM sleep deprivation was achieved by a brief treadmill movement initiated by automatic online detection of REM sleep. A yoked-control (YC) rat was placed in the same treadmill and experienced the identical movement regardless of the stage of the sleep-wake cycle. According to the results, REM sleep was reduced by 85 percent in REM sleep deprived rats and by 43 percent in YC rats. Cell proliferation was reduced by 63 percent in REM sleep deprived rats compared with YC rats. Across all animals, cell proliferation exhibited a positive correlation with the percentage of REM sleep.

“Several studies have shown that sleep contributes to brain plasticity in general, and to adult neurogenesis, in particular,” said Dr. McGinty. “Neurogenesis is a concrete example of brain plasticity, suppression of adult neurogenesis is thought to be important in pathologies such as depression. One current question has to do with the relative contribution of the two sleep states, non-REM and REM, which have very different, even opposite, physiological properties. This study showed that REM sleep has a critical role in facilitating brain plasticity. The study does not exclude an equally important role for non-REM sleep. In other recent work, we have shown that sleep fragmentation can also suppress adult neurogenesis. How sleep affects the molecular mechanisms underlying neurogenesis remains to be explored.”

It is recommended that older adults get between seven and eight hours of nightly sleep. The American Academy of Sleep Medicine (AASM) offers the following tips on how to get a good night’s sleep:

• Follow a consistent bedtime routine.
• Establish a relaxing setting at bedtime.
• Get a full night’s sleep every night.
• Avoid foods or drinks that contain caffeine, as well as any medicine that has a stimulant, prior to bedtime.
• Do not bring your worries to bed with you.
• Do not go to bed hungry, but don’t eat a big meal before bedtime either.
• Avoid any rigorous exercise within six hours of your bedtime.
• Make your bedroom quiet, dark and a little bit cool.
• Get up at the same time every morning.

In a study that may significantly advance the understanding of how cognitive-behavioral therapy affects the brain, researchers have shown that significant changes in activity in certain regions of the brain can be produced with as little as four weeks of daily therapy in patients with obsessive-compulsive disorder (OCD). The discovery could have important clinical implications, according to principal investigator Sanjaya Saxena, M.D., Director of the Obsessive-Compulsive Disorders Program at the University of California, San Diego (UCSD) School of Medicine, whose findings are published on line this week in the journal Molecular Psychiatry.

“The study is exciting because it tells us more about how cognitive-behavioral therapy works for OCD and shows that both robust clinical improvements and changes in brain activity occur after only four weeks of intensive treatment," said Saxena.

OCD is an anxiety disorder in which individuals have unreasonable fears or worries that they try to manage through ritualized compulsive behaviors to reduce the anxiety. For example, a patient may experience the urgent need to engage in certain rituals, such as hand washing or repeatedly checking that the oven is off or the front door is locked.

Past studies using functional brain imaging studies of patients with OCD have demonstrated that elevated activity along the frontal-subcortical circuits of the brain decreases in response to treatment with serotonin reuptake inhibitor (SRI) medications or cognitive-behavioral therapy. However, clinical improvement of OCD symptoms was expected to require up to 12 weeks of behavioral therapy or medication treatment, the standard treatments for OCD. Only a handful of studies have looked at how therapy affects brain function, and all previous studies had examined changes over several months of treatment.

Saxena and colleagues at the David Geffen School of Medicine at UCLA made two novel discoveries in their study of 10 OCD patients and 12 control subjects. “First of all, we discovered significant changes in brain activity solely as the result of four weeks of intensive cognitive-behavioral therapy,” said Saxena. “Secondly, these changes were different than those seen in past studies after a standard 12-week therapeutic approach using SRI medications or weekly behavioral therapy.” The researchers obtained positron emission tomography (PET) scans of the ten OCD patients both before and after they received four weeks of a therapy known as “exposure and response prevention,” which gradually desensitizes patients to things that provoke obsessional fears or worries. “This is the primary kind of therapy used for OCD. It teaches patients to pay attention to their internal experiences and tolerate scary thoughts without having to act on them,” said Saxena. “They learn that nothing terrible happens if they refrain from their usual compulsive behaviors.”

The normal control subjects received no treatment and were scanned twice, several weeks apart, and metabolic changes in the brain were compared between the two groups. After four weeks of therapy and without any changes in medication, the OCD patients showed significant improvements in OCD symptoms, depression, anxiety and overall functioning. The PET scans of OCD patients demonstrated significant decreases in glucose metabolism – a measure of brain cell activity – in the right and left thalamus after treatment. These are areas of the brain involved in OCD and where changes have been seen in numerous past studies after longer-term treatment.

However, the PET scans in this study also showed a significant increase in activity in an area of the brain called the right dorsal anterior cingulate cortex, a region involved in reappraisal and suppression of negative emotions. Increasing activity in this region corresponded to the OCD patients’ improvement in clinical symptoms after the four-week course of intensive therapy. Activity in this area had previously been found to increase after cognitive-behavioral therapy for major depression. Therefore, the researchers theorize that response to cognitive-behavioral therapy across a variety of disorders may require activation of the dorsal anterior cingulate cortex, according to Saxena.

Turner, E.H., Matthews, A.M., Linardatos, E., Tell, R.A., & Rosenthal, R. (2008). Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy. New England Journal of Medicine, 358(3). 252-260.

ABSTRACT
Background: Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials — and the outcomes within those trials — can lead to unrealistic estimates of drug effectiveness and alter the apparent risk–benefit ratio.

Methods: We obtained reviews from the Food and Drug Administration (FDA) for studies of 12 antidepressant agents involving 12,564 patients. We conducted a systematic literature search to identify matching publications. For trials that were reported in the literature, we compared the published outcomes with the FDA outcomes. We also compared the effect size derived from the published reports with the effect size derived from the entire FDA data set.

Results: Among 74 FDA-registered studies, 31%, accounting for 3449 study participants, were not published. Whether and how the studies were published were associated with the study outcome. A total of 37 studies viewed by the FDA as having positive results were published; 1 study viewed as positive was not published. Studies viewed by the FDA as having negative or questionable results were, with 3 exceptions, either not published (22 studies) or published in a way that, in our opinion, conveyed a positive outcome (11 studies). According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive. Separate meta-analyses of the FDA and journal data sets showed that the increase in effect size ranged from 11 to 69% for individual drugs and was 32% overall.

Conclusions: We cannot determine whether the bias observed resulted from a failure to submit manuscripts on the part of authors and sponsors, from decisions by journal editors and reviewers not to publish, or both. Selective reporting of clinical trial results may have adverse consequences for researchers, study participants, health care professionals, and patients.

NEJM: 17 January 2008

"No Clowning for Hospitalized Kids"
60-Second Science from Scientific American podcasts
January 17, 2008

Researchers spoke to 255 kids between the ages of 4 and 16.  And none of them liked clowns. 

According to the magazine Nursing Standard, one researcher said, “We found that clowns are universally disliked by children. Some found them frightening and unknowable.”

Find topical links to information resources that may be of interest to victims of crime. For additional information on available services in your area, visit OVC's Directory of Crime Victim Services.

BIDEN, COLLINS Resolution Designates January as National Stalking Awareness Month

Washington, DC – U.S. Senators Joseph R. Biden, Jr. (D-DE) and Susan Collins (RME) introduced a resolution designating January as National Stalking Awareness Month. This is the fifth consecutive year the Senate has considered the resolution, which applauds the efforts of policymakers, law enforcement officers, victim service providers, and other groups that currently promote stalking awareness.

“Stalking is not a one-time occurrence; this is a crime that leaves its victim fearful 24 hours a day, seven days a week. No place – not even home – is safe if a stalker knows where the victim lives. Victims spend their days and nights looking over their shoulder, often changing jobs, relocating their homes, and even changing their appearance to escape the stalker,” said Sen. Biden, author of the landmark Violence Against Women Act. In many instances, victims usually know their stalkers and 81 percent of women victims are also physically assaulted by their stalker. “January is National Stalking Awareness Month – the perfect opportunity for parents, lawmakers and community leaders to carefully review state and local laws on stalking and insist that laws keep pace with technology and protect victims.”

“I am pleased to join my colleague, Senator Biden, in introducing a Resolution marking January as National Stalking Awareness Month,” said Sen. Collins. “In my home state of Maine, domestic violence is a widespread problem. Many experts have concluded that there is a strong connection between stalking and violence toward women. Efforts, such as National Stalking Awareness Month, help raise awareness about this serious and potentially deadly crime.”

According to the National Center for Victims of Crime and the Stalking Resource Center, approximately 1 million women and 400,000 men are victims of stalking in this country annually. 1 in 12 women and 1 in 45 men will be stalked at some point in their lives, as well as close to 13 percent of female college students. Moreover, today’s technology has made stalking much easier, as stalkers can design websites to encourage others to monitor or harm their victim, install spyware on their victim’s computer or plant global positioning systems (GPS) in their victim’s car to track their victim’s travels. Other technologies, including social networking websites, such as Facebook and MySpace, cell phones with surveillance devices meant for parents monitoring their children, and running shoes implanted with GPS devices, may provide additional opportunities for stalkers to harm their victims. While all fifty states have laws against stalking, only one third of states have included language relating to stalking via electronic means.

“Stalking is a serious and potentially lethal crime,” said Mary Lou Leary, executive director of the National Center for Victims of Crime. “We thank Senators Biden and Collins for introducing this National Stalking Awareness Month resolution, which will raise awareness about the impact of stalking on more than 1.4 million Americans each year.”

“We can – and we must – do more to ensure that stalking victims are not forced to live in constant fear and that stalkers are brought to justice,” added Sen. Biden. For victim assistance, call the National Crime Victim Helpline at 1-800-FYICALL. Visit www.ncvc.org/src for a map of activities planned around the country for National Stalking Awareness Month and for more information.

QuickStats: Life Expectancy at Birth, by Race* and Sex --- United States, 1970--2005
Center for Disease Control Morbidity and Mortality Weekly Report (4 January || 56(51);1347)


* Races include non-Hispanics and Hispanics.

Longer commutes due to fewer lane changes, slower speeds

Motorists who talk on cell phones drive slower on the freeway, pass sluggish vehicles less often and take longer to complete their trips, according to a University of Utah study that suggests drivers on cell phones congest traffic.

“At the end of the day, the average person’s commute is longer because of that person who is on the cell phone right in front of them,” says University of Utah psychology Professor Dave Strayer, leader of the research team. “That SOB on the cell phone is slowing you down and making you late.”

“If you talk on the phone while you’re driving, it’s going to take you longer to get from point A to point B, and it’s going to slow down everybody else on the road,” says Joel Cooper, a doctoral student in psychology.

Cooper is scheduled to present the study in Washington on Wednesday, Jan. 16 during the Transportation Research Board’s annual meeting. The board is part of the National Academies, parent organization of the National Academy of Sciences, National Academy of Engineering and Institute of Medicine.

Cooper and Strayer conducted the study with Ivana Vladisavljevic, a doctoral student in civil and environmental engineering, and Peter Martin, an associate professor of civil and environmental engineering and director of the University of Utah Traffic Lab. Martin says that, combined with Strayer’s previous research, the new study shows “cell phones not only make driving dangerous, they cause delay too.” [read more]

Bored? Don't blame your job, the traffic or your mindless chores. Battling boredom, researchers say, means finding focus, living in the moment and having something to live for.

Anna Gosline || Scientific American Mind || December 2007